Rimón R, Kampman R, Laru-Sompa R, Heikkilä L
Pharmacopsychiatry. 1985 May;18(3):252-4. doi: 10.1055/s-2007-1017375.
Serum and CSF prolactin (PRL) concentrations were determined during eight weeks of fluphenazine medication in 28 patients with acute symptoms of schizophrenia. In both sexes a good correlation between the serum and CSF PRL values was found (r = 0.57, p less than 0.01). Throughout the entire study, first admission (FA) patients had significantly higher levels of serum and CSF PRL than the re-entry (RE) schizophrenics (0.05 greater than p less than 0.001). In addition, in FA patients, a gradual increase of the serum and CSF PRL concentrations was observed, whereas in the RE group an adaptive secretion pattern of PRL could be detected. In both patient groups, female patients exhibited significantly higher PRL serum and CSF levels than the male patients (0.05 greater than p less than 0.001). The tolerance phenomenon in the RE groups was more marked in the female than in the male patients. No correlation between clinical outcome and PRL response to fluphenazine treatment was observed. The prognostic significance of the differences in the PRL secretion pattern is discussed.
在28例有精神分裂症急性症状的患者中，测定了氟奋乃静用药八周期间的血清和脑脊液催乳素（PRL）浓度。在男女两性中，血清和脑脊液PRL值之间均发现有良好的相关性（r = 0.57，p < 0.01）。在整个研究过程中，首次入院（FA）患者的血清和脑脊液PRL水平显著高于再次入院（RE）的精神分裂症患者（0.05 > p < 0.001）。此外，在FA患者中，观察到血清和脑脊液PRL浓度逐渐升高，而在RE组中可检测到PRL的适应性分泌模式。在两组患者中，女性患者的血清和脑脊液PRL水平均显著高于男性患者（0.05 > p < 0.001）。RE组中的耐受现象在女性患者中比在男性患者中更为明显。未观察到临床结局与氟奋乃静治疗的PRL反应之间的相关性。本文讨论了PRL分泌模式差异的预后意义。
