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Interleukin 27 deficiency drives dilated cardiomyopathy by ferroptosis.

作者信息

Zhao Yan, Dai Jing, Gong Angwei, Jin Sheng, Guan Chengjian, Wang Keke, Ma Qianli, Hu Haijuan, Wu Yuming, Xiao Bing

机构信息

Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Department of Clinical Diagnostics, Hebei Medical University, Shijiazhuang, China.

出版信息

Clin Transl Med. 2025 Apr;15(4):e70269. doi: 10.1002/ctm2.70269.

DOI:10.1002/ctm2.70269
PMID:40118786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11928289/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/f15014147dbf/CTM2-15-e70269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/4fe118e4c1f1/CTM2-15-e70269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/8a65f278ae3f/CTM2-15-e70269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/a57a37a6e4bf/CTM2-15-e70269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/f15014147dbf/CTM2-15-e70269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/4fe118e4c1f1/CTM2-15-e70269-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/8a65f278ae3f/CTM2-15-e70269-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/a57a37a6e4bf/CTM2-15-e70269-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/480f/11928289/f15014147dbf/CTM2-15-e70269-g001.jpg

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本文引用的文献

1
Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity.吡哆胺可减轻阿霉素诱导的大鼠心脏毒性模型中的心脏功能障碍。
Antioxidants (Basel). 2024 Jan 17;13(1):112. doi: 10.3390/antiox13010112.
2
Dilated cardiomyopathy and chronic cardiac inflammation: Pathogenesis, diagnosis and therapy.扩张型心肌病与慢性心脏炎症：发病机制、诊断与治疗。
J Intern Med. 2023 Jan;293(1):23-47. doi: 10.1111/joim.13556. Epub 2022 Aug 27.
3
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy.肿瘤免疫治疗中的自噬、铁死亡、细胞焦亡和坏死性凋亡。
Signal Transduct Target Ther. 2022 Jun 20;7(1):196. doi: 10.1038/s41392-022-01046-3.
4
NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy.NLRP3 炎性小体介导的细胞焦亡参与非缺血性扩张型心肌病的发病机制。
Redox Biol. 2020 Jul;34:101523. doi: 10.1016/j.redox.2020.101523. Epub 2020 Mar 30.
5
Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges.白细胞介素-12家族成员在心血管疾病中的作用及机制：机遇与挑战
Front Pharmacol. 2020 Mar 4;11:129. doi: 10.3389/fphar.2020.00129. eCollection 2020.
6
IL-27 genetic variation and susceptibility of dilated cardiomyopathy in Chinese Han population.白细胞介素-27基因变异与中国汉族人群扩张型心肌病易感性
Per Med. 2017 Sep;14(5):401-408. doi: 10.2217/pme-2017-0013. Epub 2017 Sep 15.
7
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.定量蛋白质组学鉴定 NCOA4 为介导铁蛋白自噬的货物受体。
Nature. 2014 May 1;509(7498):105-9. doi: 10.1038/nature13148. Epub 2014 Mar 30.
8
Expression of functional T-cell markers and T-cell receptor Vbeta repertoire in endomyocardial biopsies from patients presenting with acute myocarditis and dilated cardiomyopathy.在表现为急性心肌炎和扩张型心肌病的患者的心肌活检标本中，功能性 T 细胞标志物和 T 细胞受体 Vβ 谱系的表达。
Eur J Heart Fail. 2011 Jun;13(6):611-8. doi: 10.1093/eurjhf/hfr014. Epub 2011 Mar 19.