Günther R W, Schild H, Fries A, Störkel S
Radiology. 1985 Aug;156(2):315-20. doi: 10.1148/radiology.156.2.4011894.
A new inferior vena caval filter was tested in an experimental series of 23 dogs and in an in vitro study. The filter consists of a pliable basket and anchoring legs made of stainless steel. It can be inserted percutaneously in an antegrade or retrograde fashion through a 10-F Teflon catheter and can be retrieved with a snare or forceps. The filter is self-orienting in the inferior vena cava, becomes securely the inferior vena cava, becomes securely fixed to the wall, and has exhibited no tendency to migrate. It is highly effective in capturing small and large emboli. There was no significant elevation in upstream hydrostatic pressure following entrapment of emboli. Spontaneous thrombus formation within the basket was observed in two of six dogs who had short-term follow-up. In dogs who had long-term follow-up, the filter remained patent. Microscopically, the filter caused sclerosis of the intima where the wire was in contact with the vessel wall. Breakage of an anchor leg and separation at the fusion between anchor and basket were seen in the study. They were eliminated by improvement of the prototype, which is now ready for clinical application.
一种新型下腔静脉滤器在23只犬的实验系列和一项体外研究中进行了测试。该滤器由一个柔韧的篮筐和由不锈钢制成的锚定腿组成。它可以通过一根10F的聚四氟乙烯导管以顺行或逆行方式经皮插入，并且可以用圈套器或镊子取出。该滤器在下腔静脉中可自行定位，能牢固地固定在下腔静脉壁上，且未显示出迁移倾向。它在捕获大小栓子方面非常有效。栓子被捕获后，上游静水压力没有显著升高。在短期随访的6只犬中，有2只观察到篮筐内有自发血栓形成。在长期随访的犬中，滤器保持通畅。显微镜下，滤器导致金属丝与血管壁接触处的内膜硬化。在研究中观察到一个锚定腿断裂以及锚与篮筐融合处分离。通过改进原型消除了这些问题，现在该原型已准备好用于临床应用。
