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评估骶管硬膜外阻滞对小儿患者视神经鞘直径的影响:随机对照研究。

Evaluating the effect of caudal epidural block on optic nerve sheath diameter in pediatric patients: randomized controlled study.

作者信息

Yayik Ahmet Murat, Ahiskalioglu Elif Oral, Celik Erkan Cem, Yalin Mirac Selcen Ozkal, Firinci Binali, Ates Irem, Aydin Muhammed Enes, Ahiskalioglu Ali

机构信息

Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, 25070, Turkey.

Clinical Research, Development and Design Application and Research Center, Ataturk University School of Medicine, Erzurum, 25240, Turkey.

出版信息

BMC Anesthesiol. 2025 Mar 22;25(1):138. doi: 10.1186/s12871-025-03007-z.

Abstract

INTRODUCTION

Caudal epidural block is a widely performed procedure for postoperative pain control of pediatric patients. As the local anesthetic acts by spreading cranially after caudal block, it may lead to several effects on the cerebrospinal fluid and intracranial region.

METHOD

Children aged 1-7, ASA I-II were included in this study. The patient population was assigned into two groups as the Caudal Block Group (Group CB) and the Control Group (Group C) Caudal block with 0.25% bupivacaine 1 ml/kg was performed on patients in Group CB. Optic nerve sheath diameter was measured at the following timeline: T: Following laryngeal mask placement, T: Following caudal block. T:15. min, T:30. min. Heart rate, non-invasive blood pressure, SpO and PCO values were also recorded at every time point.

RESULTS

There was no significant difference between two groups considering demographic data, intraoperative hemodynamic parameters, intraoperative SpO and PCO values. While optic nerve sheath diameter findings were not significantly different between the groups at T0 and T1 points(P > 0.05), the measurements at T15(4.18 ± 0.56 for Group C and 4.62 ± 0.47 for Group CB, P = 0.006) and T30(4.20 ± 0.53 for Group C and 4.76 ± 0.52 for Group CB) were statistically higher in the Caudal Group.

CONCLUSION

Evaluation of optic nerve sheath diameter has high diagnostic precision for detecting increased intracranial pressure in children. The findings in this study display that local anesthetic applied for caudal block in pediatric surgeries spread cranially resulting in an increase in the intracranial pressure and optic nerve sheath diameter. However, this increase does not cause intraoperative hemodynamic changes.

摘要

引言

骶管硬膜外阻滞是儿科患者术后疼痛控制中广泛应用的一种操作。由于局部麻醉药在骶管阻滞后置入后向头侧扩散起作用,它可能会对脑脊液和颅内区域产生多种影响。

方法

本研究纳入年龄为1至7岁、美国麻醉医师协会(ASA)分级为I-II级的儿童。将患者群体分为两组,即骶管阻滞组(CB组)和对照组(C组)。对CB组患者实施0.25%布比卡因1毫升/千克的骶管阻滞。在以下时间点测量视神经鞘直径:T0:喉罩置入后;T1:骶管阻滞后;T2:15分钟;T3:30分钟。在每个时间点还记录心率、无创血压、脉搏血氧饱和度(SpO)和二氧化碳分压(PCO)值。

结果

在人口统计学数据、术中血流动力学参数、术中SpO和PCO值方面,两组之间无显著差异。虽然在T0和T1点两组之间视神经鞘直径的测量结果无显著差异(P>0.05),但在T2(C组为4.18±0.56,CB组为4.62±0.47,P = 0.006)和T3(C组为4.20±0.53,CB组为4.76±0.52)时,骶管阻滞组的测量值在统计学上更高。

结论

对视神经鞘直径的评估在检测儿童颅内压升高方面具有较高的诊断准确性。本研究结果表明,小儿手术中用于骶管阻滞的局部麻醉药向头侧扩散,导致颅内压和视神经鞘直径增加。然而,这种增加并未引起术中血流动力学变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac68/11929278/6229ab1fc305/12871_2025_3007_Fig1_HTML.jpg

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