Van den Bogaert W, Ostyn F, van der Schueren E
Radiother Oncol. 1985 Jun;3(4):311-8. doi: 10.1016/s0167-8140(85)80044-x.
From 1962 to 1977, 90 patients with hypopharyngeal cancer were seen in the Academic Hospital in Leuven. Radiotherapy was the primary treatment in 66 patients, actuarial survival was 18% at 5 years and local control 22%. In 22 patients treated with a laryngopharyngectomy and pre- or postoperative radiotherapy, survival was also 18%, but local control was obtained in 51%. No differences in prognosis were demonstrated according to the tumoral stage or nodal status. Metastases were found in 10.5% of irradiated patients and in 14% of patients treated with combined therapy. The frequency of postoperative complications was not increased after surgery for preoperatively irradiated patients. Treatment results in hypopharyngeal cancer remain unfavorable, even with a combination of surgery and radiotherapy. Alternative approaches should be actively investigated to improve local control rates such as the modalities currently under study (high LET, new fractionations, combinations with drugs).
1962年至1977年期间，鲁汶大学学术医院共收治了90例下咽癌患者。66例患者接受了放射治疗作为主要治疗手段，5年精算生存率为18%，局部控制率为22%。22例接受喉咽切除术及术前或术后放疗的患者，生存率同样为18%，但局部控制率达51%。未发现肿瘤分期或淋巴结状态对预后有差异。接受放疗的患者中10.5%出现转移，接受联合治疗的患者中14%出现转移。术前接受放疗的患者术后手术并发症发生率并未增加。即使采用手术和放疗联合治疗，下咽癌的治疗效果仍然不佳。应积极探索其他方法以提高局部控制率，如目前正在研究的治疗方式（高传能线密度、新的分割方式、与药物联合）。
