Lukic S, Qi T, Watson Pereira C, Mandelli M L, Bogley R, Shabash M, Caverzasi E, Borghesani V, Dronkers N, Gorno-Tempini M L
UCSF-UC Berkeley Schwab Dyslexia and Cognitive Diversity Center, CA, USA; College of Communication and Information, School of Communication Sciences and Disorders, Florida State University, FL, USA.
Department of Brain Cognition and Intelligent Medicine, Beijing University of Posts and Telecommunications, Beijing, China.
Brain Lang. 2025 Jun;265:105570. doi: 10.1016/j.bandl.2025.105570. Epub 2025 Mar 21.
Developmental dyslexia (DD) is characterized by difficulties in reading but includes a general verbal short-term memory (vSTM) dysfunction. However, the behavioral and brain basis of vSTM deficits within DD are unknown. 81 children with DD and 17 typically developing (TD) children completed MRI and a verbal repetition task in which length (6 and 9-syllable phrases) and meaningfulness of phrases varied (more or less meaningful phrases). A battery of reading, phonological, and vSTM tests was administered to all children with DD. Children with DD had impaired repetition compared to TD, especially when repeating long and non-meaningful phrases. Lower repetition was associated with greater cortical thickness in the left temporoparietal area in DD. The findings enhance our understanding of one of the neurocognitive mechanisms of DD, suggesting that the repetition deficit may be related to the phonological short-term store and the auditory dorsal stream.
发育性阅读障碍（DD）的特征是阅读困难，但包括一般言语短期记忆（vSTM）功能障碍。然而，DD中vSTM缺陷的行为和大脑基础尚不清楚。81名患有DD的儿童和17名发育正常（TD）的儿童完成了MRI检查和一项言语重复任务，其中短语的长度（6和9音节短语）和意义各不相同（或多或少有意义的短语）。对所有患有DD的儿童进行了一系列阅读、语音和vSTM测试。与TD儿童相比，患有DD的儿童重复能力受损，尤其是在重复长且无意义的短语时。在DD中，较低的重复能力与左侧颞顶叶区域更大的皮质厚度相关。这些发现增进了我们对DD神经认知机制之一的理解，表明重复缺陷可能与语音短期存储和听觉背侧流有关。
