Hu Qianxing, Su Linming, Zhao Wanli, Jin Yinuo, Jin Liang, Yang Yue, Zhang Fangfang
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, China.
Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Nanjing, China.
Pharmacol Res. 2025 May;215:107705. doi: 10.1016/j.phrs.2025.107705. Epub 2025 Mar 20.
Polycomb repressive complex 1 (PRC1) is a multisubunit, evolutionarily conserved epigenetic regulator critical to numerous biological processes. Being a core component of the canonical PRC1 subunit within the Polycomb group protein complex, Chromobox4 (CBX4), a SUMO E3 ligase, can bind to H3K27me3 and recruit PRC1. This ligase regulates the SUMOylation of various proteins and permits their post-translational modification under different physiological conditions. CBX4 has been reported to regulate the development of senescence and various diseases in vivo. This review delves into the physiological functions and action mechanisms of CBX4 across different tissues and cells, particularly focusing on its primarily roles in migration, cellular senescence, metabolic dysregulation, inflammation development, and tumor proliferation. Targeting CBX4 offers a therapeutic potential for delaying cell senescence and suppressing tumor growth.
多梳抑制复合物1（PRC1）是一种多亚基的、进化保守的表观遗传调节因子，对众多生物学过程至关重要。作为多梳蛋白复合物中经典PRC1亚基的核心成分，SUMO E3连接酶染色体框蛋白4（CBX4）可与H3K27me3结合并募集PRC1。这种连接酶调节各种蛋白质的SUMO化，并使其在不同生理条件下进行翻译后修饰。据报道，CBX4在体内调节衰老和各种疾病的发展。本综述深入探讨了CBX4在不同组织和细胞中的生理功能及作用机制，尤其关注其在迁移、细胞衰老、代谢失调、炎症发展和肿瘤增殖中的主要作用。靶向CBX4为延缓细胞衰老和抑制肿瘤生长提供了治疗潜力。
