van der Meer Matthijs A A, Bendor Daniel
Department of Psychological & Brain Sciences, Dartmouth College, Hanover, NH 03755, USA.
Institute of Behavioural Neuroscience, Dept. of Experimental Psychology, University College London, London, UK.
Trends Neurosci. 2025 Apr;48(4):257-267. doi: 10.1016/j.tins.2025.02.006. Epub 2025 Mar 22.
Hippocampal replay is widely thought to support two key cognitive functions: online decision-making and offline memory consolidation. In this review, we take a closer look at the hypothesized link between awake replay and online decision-making in rodents, and find only marginal evidence in support of this role. By contrast, the consolidation view is bolstered by new computational ideas and recent data, suggesting that (i) replay performs offline fictive learning for later goal-oriented behavior; and (ii) replay tags memories prior to sleep, prioritizing them for consolidation. Based on these recent advances, we favor an updated and refined role for awake replay - that is, supporting prioritized offline learning and tagging outside the hippocampus - rather than a direct, online role in guiding behavior.
在线决策和离线记忆巩固。在这篇综述中，我们更深入地研究了啮齿动物清醒时重演与在线决策之间的假设联系，结果发现仅有少量证据支持这一作用。相比之下，新的计算思路和近期数据支持了巩固观点，表明：（i）重演进行离线虚拟学习以用于后续的目标导向行为；（ii）重演在睡眠前标记记忆，将它们优先进行巩固。基于这些最新进展，我们支持对清醒时重演作用进行更新和细化，即支持海马体外的优先离线学习和标记，而非在指导行为中发挥直接的在线作用。
