Chavda Vivek P, Joshi Disha
Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India.
Department of Pharmaceutical Technology, L. J. Institute of Pharmacy, L J University, Ahmedabad, Gujarat, India.
Prog Mol Biol Transl Sci. 2025;212:389-438. doi: 10.1016/bs.pmbts.2024.12.001. Epub 2025 Jan 27.
Surface modification of proteins and peptides has emerged as a promising strategy to enhance their therapeutic efficacy and target specificity. This chapter delves into the various techniques employed to modify the surface properties of these biomolecules, including chemical conjugation, site-specific mutagenesis, and peptide synthesis. The focus is on strategies that improve drug delivery to specific target sites, such as tumor cells or inflamed tissues. By modifying surface properties, it is possible to enhance drug stability, reduce immunogenicity, and prolong circulation time. This chapter explores the latest advancements in this field and discusses the potential applications of surface-modified proteins and peptides in the development of novel therapeutic agents.
蛋白质和肽的表面修饰已成为一种有前景的策略，可提高其治疗效果和靶向特异性。本章深入探讨了用于修饰这些生物分子表面性质的各种技术，包括化学偶联、位点特异性诱变和肽合成。重点是改善药物向特定靶位点（如肿瘤细胞或炎症组织）递送的策略。通过修饰表面性质，可以提高药物稳定性、降低免疫原性并延长循环时间。本章探讨了该领域的最新进展，并讨论了表面修饰的蛋白质和肽在新型治疗药物开发中的潜在应用。
