Nakoui Naimeh, Ilbeigi Saeed, Ahmadi Mohsen Mohammadnia, Saber Azadeh
Faculty of Sports Sciences, University of Birjand, Birjand, Iran.
Kerman University of Medical Sciences, Kerman, Iran.
Sci Rep. 2025 Mar 24;15(1):10052. doi: 10.1038/s41598-025-94257-x.
Although hemodialysis has been able to increase the lifespan of dialysis patients, it has also brought many problems such as fatigue, low QOL, hypertension and physical weakness to them. Therefore, the aim of this study was to compare the effect of aerobic and resistance training on fatigue, quality of life (QOL), blood Na, hemoglobin, C-reactive protein (CRP) and urea-creatinine ratio in hemodialysis patients. This research was conducted on 51 patients in two dialysis centers in Kerman, Iran. Patients were randomly divided into resistance group (RG) (n = 17), aerobic group (AG) (n = 17) and control group (CG) (n = 17). The patients in RG and AG performed the training protocol for eight weeks. Research variables as fatigue, QOL, blood Na, hemoglobin, CRP, and urea-creatinine ratio were measured in pre-test and post-test. Data analysis was done using one-way ANOVA and Tukey's post hoc tests in SPSS25. (p < 0.05). The mean level of fatigue in RG and AG was significantly lower than the CG (p = 0.001). The mean levels of blood Na in AG was significantly higher than RG and CG (p = 0.01). Also, the mean ratio of urea-creatinine in RG and AG were significantly lower than CG (p = 0.001). There was no significant difference in QOL, hemoglobin and CRP between the RG and AG compared to the CG (p > 0.05). Based on our evidence, resistance and aerobic training for 8 weeks, 3 times weekly, is likely to improve the conditions of hemodialysis patients, and might be an option to increase intradialytic exercise adherence. Future studies should determine whether the findings are generalizable and examine the long-term effects of intradialytic exercise training.
尽管血液透析能够延长透析患者的寿命，但也给他们带来了许多问题，如疲劳、生活质量低下、高血压和身体虚弱。因此，本研究的目的是比较有氧运动和抗阻训练对血液透析患者疲劳、生活质量（QOL）、血钠、血红蛋白、C反应蛋白（CRP）和尿素肌酐比值的影响。本研究在伊朗克尔曼的两个透析中心对51例患者进行。患者被随机分为抗阻训练组（RG）（n = 17）、有氧运动组（AG）（n = 17）和对照组（CG）（n = 17）。RG组和AG组的患者进行了为期八周的训练方案。在测试前和测试后测量研究变量，如疲劳、QOL、血钠、血红蛋白、CRP和尿素肌酐比值。使用SPSS25中的单因素方差分析和Tukey事后检验进行数据分析（p < 0.05）。RG组和AG组的平均疲劳水平显著低于CG组（p = 0.001）。AG组的平均血钠水平显著高于RG组和CG组（p = 0.01）。此外，RG组和AG组的尿素肌酐平均比值显著低于CG组（p = 0.001）。与CG组相比，RG组和AG组在QOL、血红蛋白和CRP方面没有显著差异（p > 0.05）。根据我们的证据，每周三次、为期8周的抗阻训练和有氧运动可能会改善血液透析患者的状况，并且可能是增加透析期间运动依从性的一种选择。未来的研究应确定这些发现是否具有普遍性，并研究透析期间运动训练的长期影响。
