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Impact of daratumumab on the development of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.

作者信息

Minakata Daisuke, Fujiwara Shin-Ichiro, Honda Seina, Tominaga Ryutaro, Yokoyama Daizo, Noguchi Atsuto, Furuki Shuka, Koyama Shunsuke, Murahashi Rui, Nakashima Hirotomo, Hyodo Kazuki, Kawaguchi Shin-Ichiro, Ikeda Takashi, Toda Yumiko, Mashima Kiyomi, Umino Kento, Ueda Masuzu, Ashizawa Masahiro, Yamamoto Chihiro, Hatano Kaoru, Sato Kazuya, Ohmine Ken, Fukushima Noriyoshi, Kanda Yoshinobu

机构信息

Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Division of Cell Transplantation and Transfusion, Jichi Medical University, Tochigi, Japan.

出版信息

Bone Marrow Transplant. 2025 May;60(5):743-745. doi: 10.1038/s41409-025-02558-6. Epub 2025 Mar 23.

DOI:10.1038/s41409-025-02558-6
PMID:40123005
Abstract
摘要

相似文献

1
Impact of daratumumab on the development of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.达雷妥尤单抗对多发性骨髓瘤自体外周血干细胞移植后植入综合征发生的影响。
Bone Marrow Transplant. 2025 May;60(5):743-745. doi: 10.1038/s41409-025-02558-6. Epub 2025 Mar 23.
2
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.在新诊断的多发性骨髓瘤中，用包含达雷妥尤单抗和来那度胺的四联诱导治疗进行干细胞动员的结果：来自 MASTER 和 GRIFFIN 试验的结果。
Transplant Cell Ther. 2023 Mar;29(3):174.e1-174.e10. doi: 10.1016/j.jtct.2022.11.029. Epub 2022 Dec 6.
3
Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.新型免疫调节剂和环磷酰胺对多发性骨髓瘤自体外周血造血干细胞移植后植入综合征风险的不同影响。
Biol Blood Marrow Transplant. 2013 Sep;19(9):1368-73. doi: 10.1016/j.bbmt.2013.06.017. Epub 2013 Jun 24.
4
Impact of daratumumab on stem cell mobilization and collection, engraftment and early post-transplant complications among multiple myeloma patients undergoing autologous stem cell transplantation.达雷妥尤单抗对多发性骨髓瘤患者自体干细胞移植中干细胞动员和采集、植入和移植后早期并发症的影响。
Leuk Lymphoma. 2023 Dec;64(13):2140-2147. doi: 10.1080/10428194.2023.2253479. Epub 2023 Sep 1.
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Use of Non-Cryopreserved Peripheral Blood Stem Cells Is Associated with Adequate Engraftment in Patients with Multiple Myeloma Undergoing an Autologous Transplant.非冷冻保存的外周血干细胞的使用与多发性骨髓瘤患者自体移植后适当植入相关。
Biol Blood Marrow Transplant. 2018 Dec;24(12):e31-e35. doi: 10.1016/j.bbmt.2018.08.007. Epub 2018 Aug 22.
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First-Line Use of Daratumumab in Patients with Multiple Myeloma Shows Delayed Neutrophil and Platelet Engraftment after Autologous Stem Cell Transplantation: Results from a Real-Life Single-Center Study.达雷妥尤单抗在多发性骨髓瘤患者中的一线应用显示自体干细胞移植后中性粒细胞和血小板植入延迟：一项真实世界单中心研究的结果
Cancers (Basel). 2024 Sep 27;16(19):3307. doi: 10.3390/cancers16193307.
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Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study.硼替佐米、沙利度胺和地塞米松联合或不联合达雷妥尤单抗用于新诊断多发性骨髓瘤患者自体造血干细胞移植前后（CASSIOPEIA）：一项随机、开放标签、3 期研究。
Lancet. 2019 Jul 6;394(10192):29-38. doi: 10.1016/S0140-6736(19)31240-1. Epub 2019 Jun 3.
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[Daratumumab maintenance after autologous hematopoietic stem cell transplantation for newly diagnosed multiple myeloma].[达雷妥尤单抗用于新诊断多发性骨髓瘤自体造血干细胞移植后的维持治疗]
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Outcomes of stem cell mobilization and engraftment in patients with multiple myeloma according to CD56 expression status.根据 CD56 表达状态评估多发性骨髓瘤患者的干细胞动员和植入效果。
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Daratumumab during Myeloma Induction Therapy Is Associated with Impaired Stem Cell Mobilization and Prolonged Post-Transplant Hematologic Recovery.达雷妥尤单抗用于骨髓瘤诱导治疗时与干细胞动员受损及移植后血液学恢复延长相关。
Cancers (Basel). 2024 May 13;16(10):1854. doi: 10.3390/cancers16101854.

本文引用的文献

1
Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.达雷妥尤单抗、硼替佐米、来那度胺和地塞米松治疗多发性骨髓瘤。
N Engl J Med. 2024 Jan 25;390(4):301-313. doi: 10.1056/NEJMoa2312054. Epub 2023 Dec 12.
2
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.达雷妥尤单抗、来那度胺、硼替佐米和地塞米松用于适合移植的新诊断多发性骨髓瘤：GRIFFIN 试验。
Blood. 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288.
3
Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open-label, phase 3 study.
硼替佐米、沙利度胺和地塞米松联合或不联合达雷妥尤单抗用于新诊断多发性骨髓瘤患者自体造血干细胞移植前后（CASSIOPEIA）：一项随机、开放标签、3 期研究。
Lancet. 2019 Jul 6;394(10192):29-38. doi: 10.1016/S0140-6736(19)31240-1. Epub 2019 Jun 3.
4
Comparison of minimal residual disease detection in multiple myeloma by SRL 8-color single-tube and EuroFlow 8-color 2-tube multiparameter flow cytometry.采用SRL 8色单管和EuroFlow 8色2管多参数流式细胞术检测多发性骨髓瘤微小残留病的比较
Int J Hematol. 2019 Apr;109(4):377-381. doi: 10.1007/s12185-019-02615-z. Epub 2019 Feb 18.
5
Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Mitigate Immunosuppression in Multiple Myeloma.靶向 CD38 抑制调节性 T 细胞的诱导和功能，减轻多发性骨髓瘤中的免疫抑制。
Clin Cancer Res. 2017 Aug 1;23(15):4290-4300. doi: 10.1158/1078-0432.CCR-16-3192. Epub 2017 Mar 1.
6
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma.达雷妥尤单抗可清除CD38+免疫调节细胞，促进T细胞扩增，并使多发性骨髓瘤中的T细胞库发生偏移。
Blood. 2016 Jul 21;128(3):384-94. doi: 10.1182/blood-2015-12-687749. Epub 2016 May 24.