Jiang Haidong, Xu Siyan, Xiang Xiaomeng, Zhao Mengfan, Wang Ying, Liu Xiangyu, Liu Bing, Chen Qing
Shanghai University of Sport, 399 Changhai Road, Shanghai 200438, China.
Research Institute for Doping Control, Shanghai University of Sport, Shanghai 200438, China.
ACS Omega. 2025 Mar 3;10(10):9890-9902. doi: 10.1021/acsomega.4c11671. eCollection 2025 Mar 18.
Metal-Organic Frameworks (MOFs), as a new type of porous material, have attracted widespread attention in the fields of chemistry, materials science, and biomedicine owing to their unique structural characteristics and potential for functionalization. This review summarizes the latest research progress of MOFs in the field of steroid compounds, including the latest research progress of MOFs in the purification and separation of steroids, sensing and detection, catalytic transformation, and drug delivery. First, we explore how the porous structure and chemical functionalization of MOFs achieve efficient separation and purification of steroid compounds. Second, the high sensitivity and selectivity of MOFs as sensing materials in steroid detection, as well as their application potential in actual sample analysis, are analyzed. Furthermore, the role of MOFs in steroid catalytic transformation reactions is discussed, including their performance as catalysts or catalyst carriers. Finally, we focus on the innovative applications of MOFs in drug delivery systems, especially their advantages in controlled release and targeted drug delivery. This article also explores the future development trends and application prospects of MOFs in the field of steroids, highlighting the challenges and opportunities in material design, functionalization strategies, and practical implementations. Through this review, we aim to provide a comprehensive theoretical basis and practical guidance for further research and application of MOFs in the field of steroids.
金属有机框架材料(MOFs)作为一种新型多孔材料,因其独特的结构特性和功能化潜力,在化学、材料科学和生物医学领域引起了广泛关注。本文综述了MOFs在甾体化合物领域的最新研究进展,包括MOFs在甾体化合物的纯化与分离、传感与检测、催化转化及药物递送方面的最新研究进展。首先,我们探讨了MOFs的多孔结构和化学功能化如何实现甾体化合物的高效分离与纯化。其次,分析了MOFs作为传感材料在甾体检测中的高灵敏度和选择性,以及它们在实际样品分析中的应用潜力。此外,还讨论了MOFs在甾体催化转化反应中的作用,包括其作为催化剂或催化剂载体的性能。最后,我们重点关注MOFs在药物递送系统中的创新应用,尤其是它们在控释和靶向药物递送方面的优势。本文还探讨了MOFs在甾体领域的未来发展趋势和应用前景,突出了材料设计、功能化策略及实际应用中的挑战与机遇。通过这篇综述,我们旨在为MOFs在甾体领域的进一步研究和应用提供全面的理论基础和实践指导。