Wang Hailin, Yang Ying, Ni Ziwei, Qiao Xiaoting, Guo Yaqian, Wang Xiaomin, Cao Duo, Wang Yayun, Ruan Cailian
Medical School of Yan'an University, Yan'an, Shaanxi 716000, China.
Shaanxi Institute for Pediatric Diseases, Xi'an Children's Hospital, Xi'an, China.
IBRO Neurosci Rep. 2025 Feb 26;18:409-413. doi: 10.1016/j.ibneur.2025.02.010. eCollection 2025 Jun.
Neurodevelopmental disorders (NDDs) constitute a heterogeneous group of early-onset brain dysfunction disorders, which may arise from genetic or acquired etiologies. These disorders are characterized by behavioral and cognitive deficits that predominantly manifest during childhood development, thereby potentially impairing an individual's performance in learning, sports, and social situations. A comprehensive understanding of the pathogenesis of NDDs is crucial for the development of targeted therapeutic interventions. Zinc-finger transcription factors (ZFPs) play a pivotal role in regulating gene expression by modulating the binding of RNA polymerase to DNA, thereby either activating or repressing gene transcription. In recent years, the gene family of ZFPs has garnered significant attention due to its critical involvement in nervous system development. This review aims to elucidate the structure and molecular functions of the gene family, discuss its impact on the development of the central nervous system, and explore its association with neurodevelopmental disorders.
神经发育障碍（NDDs）是一组异质性的早发性脑功能障碍疾病，其病因可能是遗传或后天获得性的。这些疾病的特征是行为和认知缺陷，主要在儿童发育过程中表现出来，从而可能损害个体在学习、运动和社交场合中的表现。全面了解NDDs的发病机制对于开发针对性的治疗干预措施至关重要。锌指转录因子（ZFPs）通过调节RNA聚合酶与DNA的结合来调控基因表达，从而激活或抑制基因转录，在这一过程中发挥关键作用。近年来，ZFPs基因家族因其在神经系统发育中的关键作用而备受关注。本综述旨在阐明该基因家族的结构和分子功能，讨论其对中枢神经系统发育的影响，并探讨其与神经发育障碍的关联。
