Wen Yuan, Zhang Yuanyuan, Lv Qingquan, Lan Weiqun, Shu Yi, Qi Qiuhuan, Hu Hongping, Saleh Othman Zakaria
Department of Cardiovascular Medicine, Wuhan Hankou Hospital, Wuhan, China.
Department of Medical Affairs, Wuhan Hankou Hospital, Wuhan, China.
Front Cardiovasc Med. 2025 Mar 7;12:1421923. doi: 10.3389/fcvm.2025.1421923. eCollection 2025.
Coronary heart disease (CHD) is a pervasive chronic condition that poses a significant threat to global health and mortality worldwide. Given the severity of this disease, it is imperative to consider pivotal factors such as age, concurrent diseases, and physical frailty of patients diagnosed with ischemic non-obstructive CHD prior to initiating cardiopulmonary rehabilitation. Consequently, the objective of this study is to investigate the impact of an individualized exercise rehabilitation program, on the ischemic burden in patients suffering from ischemic non-obstructive CHD.
From February 2019 to July 2021, a cohort of one hundred patients diagnosed with ischemic non-obstructive CHD were recruited and randomly allocated into two groups. The control group underwent a standard rehabilitation program, while the intervention group participated in an individualized exercise rehabilitation program. This program was tailored to each patient, with a 50% power intensity exercise prescription derived from the results of the patient's Cardiopulmonary Exercise Testing (CPET) evaluation. The therapeutic effect, total myocardial ischemic burden (TIB), the effective rate of TIB reduction, pulmonary function indices, cardiac function, and the incidence of adverse events compared between the two groups.
The intervention group demonstrated a higher effective rate. TIB in the intervention group was significantly reduced at the 1,2, and 4-week marks post-intervention and exhibited a higher effective rate of total myocardial ischemia load reduction. Post-intervention, there were improvements in the Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), and the FEV1/FVC ratio, with the intervention group showing higher values for these parameters. Cardiac function was enhanced following the intervention, with the intervention group displaying higher Left Ventricular Ejection Fraction (LVEF) and Carbon Monoxide (CO) levels, and a lower Left Ventricular End-Diastolic Dimension (LVEDD) compared to the control group ( < 0.05).
An individualized exercise rehabilitation regimen for patients diagnosed with ischemic non-obstructive CHD can effectively compensate for the lack of physical activity. This regimen has demonstrated its ability to enhance the clinical therapeutic effect, reduce the total load of myocardial ischemia, improve pulmonary function indices and cardiac function, and decrease the incidence of cardiovascular adverse events.
identifier (TJ-IRB20210716).
冠心病（CHD）是一种普遍存在的慢性疾病，对全球健康和死亡率构成重大威胁。鉴于这种疾病的严重性，在启动心肺康复之前，必须考虑诸如年龄、并发疾病以及缺血性非阻塞性冠心病患者的身体虚弱等关键因素。因此，本研究的目的是调查个性化运动康复计划对缺血性非阻塞性冠心病患者缺血负担的影响。
从2019年2月至2021年7月，招募了100名被诊断为缺血性非阻塞性冠心病的患者，并将其随机分为两组。对照组接受标准康复计划，而干预组参加个性化运动康复计划。该计划是根据每位患者量身定制的，50%的功率强度运动处方来自患者心肺运动试验（CPET）评估的结果。比较两组之间的治疗效果、总心肌缺血负担（TIB）、TIB降低有效率、肺功能指标、心功能以及不良事件的发生率。
干预组显示出更高的有效率。干预组的TIB在干预后1周、2周和4周时显著降低，并且总心肌缺血负荷降低的有效率更高。干预后，用力肺活量（FVC）、一秒用力呼气量（FEV1）和FEV1/FVC比值有所改善，干预组这些参数的值更高。干预后心功能得到增强，与对照组相比，干预组的左心室射血分数（LVEF）和一氧化碳（CO）水平更高，左心室舒张末期内径（LVEDD）更低（<0.05）。
针对缺血性非阻塞性冠心病患者的个性化运动康复方案可以有效弥补体力活动的不足。该方案已证明其能够提高临床治疗效果，降低心肌缺血的总负荷，改善肺功能指标和心功能，并降低心血管不良事件的发生率。
标识符（TJ-IRB20210716）。
