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Hiding in Plain Sight: FDA-Approved Cholesterol Drug Ezetimibe as a Treatment for Alzheimer's.

作者信息

Gorbunova Vera, Seluanov Andrei

机构信息

University of Rochester, Rochester, NY, USA.

出版信息

Aging Biol. 2024;2. doi: 10.59368/agingbio.20240037. Epub 2024 Oct 23.

DOI:10.59368/agingbio.20240037
PMID:40124644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11927789/
Abstract
摘要

相似文献

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Aging Biol. 2024;2. doi: 10.59368/agingbio.20240037. Epub 2024 Oct 23.
2
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Neurology. 2024 Jan 23;102(2):e208063. doi: 10.1212/WNL.0000000000208063. Epub 2023 Dec 19.
3
Potential of ezetimibe in memory deficits associated with dementia of Alzheimer's type in mice.依泽替米贝对阿尔茨海默病相关痴呆小鼠记忆缺陷的作用。
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Front Integr Neurosci. 2022 May 25;16:896400. doi: 10.3389/fnint.2022.896400. eCollection 2022.
5
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Antiviral Res. 2018 Dec;160:151-164. doi: 10.1016/j.antiviral.2018.10.024. Epub 2018 Nov 1.
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Inhibition of intestinal absorption of cholesterol by ezetimibe or bile acids by SC-435 alters lipoprotein metabolism and extends the lifespan of SR-BI/apoE double knockout mice.依折麦布抑制肠道胆固醇吸收或SC-435抑制胆汁酸吸收可改变脂蛋白代谢并延长SR-BI/apoE双敲除小鼠的寿命。
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Expert Opin Drug Saf. 2015;14(9):1445-55. doi: 10.1517/14740338.2015.1063613. Epub 2015 Jul 3.

本文引用的文献

1
Ezetimibe Lowers Risk of Alzheimer's and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction.依折麦布将患阿尔茨海默病及相关痴呆症的风险降低逾七倍,通过抑制14-3-3G::己糖激酶相互作用减少模型系统中的聚集。
Aging Biol. 2024;2. doi: 10.59368/agingbio.20240028. Epub 2024 Jun 26.
2
Misfolding and aggregation in neurodegenerative diseases: protein quality control machinery as potential therapeutic clearance pathways.神经退行性疾病中的错误折叠和聚集:蛋白质质量控制机制作为潜在的治疗性清除途径。
Cell Commun Signal. 2024 Aug 30;22(1):421. doi: 10.1186/s12964-024-01791-8.
3
Cardiovascular disease, associated risk factors, and risk of dementia: An umbrella review of meta-analyses.心血管疾病、相关危险因素与痴呆风险:一项荟萃分析的伞状综述
Front Epidemiol. 2023 Feb 9;3:1095236. doi: 10.3389/fepid.2023.1095236. eCollection 2023.
4
Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer's disease by targeted small molecules.靶向小分子挽救阿尔茨海默病中 ApoE4 相关溶酶体自噬失败。
Commun Biol. 2024 Jan 8;7(1):60. doi: 10.1038/s42003-024-05767-9.
5
Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases.靶向神经退行性疾病中 14-3-3 及其相互作用伙伴的生理后果。
Int J Mol Sci. 2022 Dec 7;23(24):15457. doi: 10.3390/ijms232415457.
6
Blood cholesterol and risk of dementia in more than 1·8 million people over two decades: a retrospective cohort study.二十多年来,180 多万人的血液胆固醇与痴呆风险:一项回顾性队列研究。
Lancet Healthy Longev. 2021 Aug;2(8):e498-e506. doi: 10.1016/S2666-7568(21)00150-1. Epub 2021 Jul 23.
7
Early increase of cerebrospinal fluid 14-3-3ζ protein in the alzheimer's disease continuum.阿尔茨海默病连续体中脑脊液14-3-3ζ蛋白的早期增加。
Front Aging Neurosci. 2022 Jul 29;14:941927. doi: 10.3389/fnagi.2022.941927. eCollection 2022.
8
Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin-deficient and mdx mice.胆固醇吸收抑制剂依泽替米贝可预防严重肌营养不良症和 mdx 小鼠的肌肉消耗。
J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):544-560. doi: 10.1002/jcsm.12879. Epub 2021 Dec 19.
9
Statin use and risk of dementia or Alzheimer's disease: a systematic review and meta-analysis of observational studies.他汀类药物的使用与痴呆症或阿尔茨海默病风险:观察性研究的系统评价和荟萃分析
Eur J Prev Cardiol. 2022 May 5;29(5):804-814. doi: 10.1093/eurjpc/zwab208.
10
Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats.依泽替米贝通过 AMPK/Nrf2/TXNIP 通路减轻大鼠 MCAO 后的氧化应激和神经炎症。
Oxid Med Cell Longev. 2020 Jan 4;2020:4717258. doi: 10.1155/2020/4717258. eCollection 2020.