Keen Adam, Zhang Feiran, Reader John S, Tzima Ellie
Wellcome Centre for Human Genetics, Radcliffe Department of Medicine, University of Oxford, United Kingdom.
Curr Opin Physiol. 2023 Aug;34:None. doi: 10.1016/j.cophys.2023.100673.
Endothelial homeostasis is a central feature of vascular health. The vascular endothelium is under constant mechanical stress resulting from blood flow and, therefore, requires a high degree of resilience to adapt to stresses and resist development of disease. In this review, we discuss the molecular mechanisms by which the endothelium maintains proteostasis in response to haemodynamic forces by regulating three key areas: protein synthesis, recycling and degradation.
内皮稳态是血管健康的核心特征。血管内皮不断受到血流产生的机械应力影响，因此需要高度的弹性来适应压力并抵抗疾病的发展。在本综述中，我们讨论内皮通过调节蛋白质合成、循环利用和降解这三个关键领域来响应血流动力学力从而维持蛋白质稳态的分子机制。
