Baysal Serdar, Şahin Didem, Sezer Serdar, Yayla Müçteba E, Uslu Emine, Ateş Aşkın, Turgay Tahsin M, Kinikli Gülay
Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
J Scleroderma Relat Disord. 2025 Mar 19:23971983251322841. doi: 10.1177/23971983251322841.
Systemic sclerosis was found to be associated with an increase in cancer incidence. The target of this study was to investigate the most common malignancies and to identify factors that increase the cancer risk in systemic sclerosis patients.
In this single-centre retrospective study, we screened 252 patients attending our outpatient clinic between January 2005 and December 2021.
A total of 252 systemic sclerosis patients were included in the study. Data for the patients were obtained by evaluating their medical records retrospectively. A total of 252 patients with systemic sclerosis were analysed. Nineteen patients were diagnosed with malignancies. Lung cancer was the most common malignancy among patients. Malignancies were not correlated with sex, follow-up period, type of systemic sclerosis, organ involvement, smoking history, serological tests, comorbidities, dose and duration of disease-modifying antirheumatic drugs (DMARDs), but advanced age at systemic sclerosis diagnosis increased the risk of malignancy (p = 0.017) in systemic sclerosis patients.
In the current study, advanced age at systemic sclerosis diagnosis was determined to be an extra risk factor for the initiation of cancer in systemic sclerosis patients. Particularly in this patient group, additional screenings might be helpful for early diagnosis. Treatments such as methotrexate, cyclophosphamide, azathioprine, and mycophenolate mofetil can be used without additional cancer risk.
系统性硬化症被发现与癌症发病率增加有关。本研究的目的是调查最常见的恶性肿瘤，并确定增加系统性硬化症患者癌症风险的因素。
在这项单中心回顾性研究中，我们筛选了2005年1月至2021年12月期间在我们门诊就诊的252例患者。
本研究共纳入252例系统性硬化症患者。通过回顾性评估他们的病历获得患者数据。共分析了252例系统性硬化症患者。19例患者被诊断为恶性肿瘤。肺癌是患者中最常见的恶性肿瘤。恶性肿瘤与性别、随访时间、系统性硬化症类型、器官受累情况、吸烟史、血清学检查、合并症、改善病情抗风湿药物（DMARDs）的剂量和疗程无关，但系统性硬化症诊断时的高龄增加了系统性硬化症患者发生恶性肿瘤的风险（p = 0.017）。
在本研究中，系统性硬化症诊断时的高龄被确定为系统性硬化症患者发生癌症的额外风险因素。特别是在这个患者群体中，额外的筛查可能有助于早期诊断。甲氨蝶呤、环磷酰胺、硫唑嘌呤和霉酚酸酯等治疗方法可在不增加额外癌症风险的情况下使用。
