癌症和硬皮病。
Cancer and Scleroderma.
机构信息
Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F. Lord Building, Center Tower, Suite 4100, Baltimore, MD 21224, USA.
Division of Rheumatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Mason F. Lord Building, Center Tower, Suite 4100, Baltimore, MD 21224, USA.
出版信息
Rheum Dis Clin North Am. 2020 Aug;46(3):551-564. doi: 10.1016/j.rdc.2020.03.002. Epub 2020 Jun 10.
Abstract
Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.
摘要
硬皮病患者的癌症发病率高于普通人群。这种风险增加可能源于慢性炎症和组织损伤、免疫抑制治疗引起的恶性转化，或是共同的激发因素。在硬皮病的某些特定患者亚群中，癌症与硬皮病的发病之间存在密切的时间关系，提示癌症引起的自身免疫。本文讨论了癌症与硬皮病之间潜在的机制联系、硬皮病患者癌症风险增加相关的血清学和临床危险因素，以及癌症筛查的意义。
相似文献
1
Cancer and Scleroderma.癌症和硬皮病。
Rheum Dis Clin North Am. 2020 Aug;46(3):551-564. doi: 10.1016/j.rdc.2020.03.002. Epub 2020 Jun 10.
2
Cancer and systemic sclerosis: novel insights into pathogenesis and clinical implications.癌症与系统性硬化症：发病机制的新见解及其临床意义。
Curr Opin Rheumatol. 2011 Nov;23(6):530-5. doi: 10.1097/BOR.0b013e32834a5081.
3
Cancer and scleroderma: a paraneoplastic disease with implications for malignancy screening.癌症与硬皮病：一种具有恶性肿瘤筛查意义的副肿瘤性疾病。
Curr Opin Rheumatol. 2015 Nov;27(6):563-70. doi: 10.1097/BOR.0000000000000222.
4
Cancer risk in systemic sclerosis: identifying risk and managing high-risk patients.系统性硬化症中的癌症风险：识别风险并管理高危患者。
Expert Rev Clin Immunol. 2020 Dec;16(12):1105-1113. doi: 10.1080/1744666X.2021.1847641. Epub 2020 Nov 16.
5
Mechanistic and clinical insights at the scleroderma-cancer interface.硬皮病与癌症交叉领域的机制及临床见解。
J Scleroderma Relat Disord. 2017 Sep-Dec;2(3):153-159. doi: 10.5301/jsrd.5000250. Epub 2017 Oct 5.
6
Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors.癌症与系统性硬化症之间的有趣关系：免疫系统和其他因素的作用。
Front Immunol. 2019 Jan 10;9:3112. doi: 10.3389/fimmu.2018.03112. eCollection 2018.
7
Cancer and scleroderma: recent insights.癌症与硬皮病：最新见解。
Curr Opin Rheumatol. 2020 Nov;32(6):479-487. doi: 10.1097/BOR.0000000000000755.
8
Examination of autoantibody status and clinical features associated with cancer risk and cancer-associated scleroderma.检查与癌症风险和癌症相关硬皮病相关的自身抗体状态和临床特征。
Arthritis Rheumatol. 2015 Apr;67(4):1053-61. doi: 10.1002/art.39022.
9
Malignancies in Patients with Anti-RNA Polymerase III Antibodies and Systemic Sclerosis: Analysis of the EULAR Scleroderma Trials and Research Cohort and Possible Recommendations for Screening.抗RNA聚合酶III抗体与系统性硬化症患者的恶性肿瘤：欧洲抗风湿病联盟硬皮病试验与研究队列分析及筛查建议
J Rheumatol. 2017 May;44(5):639-647. doi: 10.3899/jrheum.160817. Epub 2017 Jan 15.
10
Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma.简报：抗 RNA 聚合酶 III 抗体作为癌症相关硬皮病的标志物。
Arthritis Rheumatol. 2017 Jun;69(6):1306-1312. doi: 10.1002/art.40065.
引用本文的文献
1
Malignancy-associated risk factors in patients with systemic sclerosis.系统性硬化症患者的恶性肿瘤相关危险因素
J Scleroderma Relat Disord. 2025 Mar 19:23971983251322841. doi: 10.1177/23971983251322841.
2
Mindin regulates fibroblast subpopulations through distinct Src family kinases during fibrogenesis.在纤维化形成过程中，Mindin通过不同的Src家族激酶调节成纤维细胞亚群。
JCI Insight. 2024 Dec 31;10(3):e173071. doi: 10.1172/jci.insight.173071.
3
Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis.系统性硬化症中广泛的突变和染色体不稳定性塑造了体细胞基因组。
Nat Commun. 2024 Oct 15;15(1):8889. doi: 10.1038/s41467-024-53332-z.
4
A Case of Scleroderma With Coexisting Multiple Myeloma and Bullous Pemphigoid.一例硬皮病合并多发性骨髓瘤和大疱性类天疱疮病例。
Cureus. 2024 Aug 10;16(8):e66568. doi: 10.7759/cureus.66568. eCollection 2024 Aug.
5
Biomarkers reflecting the pathogenesis, clinical manifestations, and guide therapeutic approach in systemic sclerosis: a narrative review.反映系统性硬化症发病机制、临床表现和指导治疗方法的生物标志物：叙述性综述。
Clin Rheumatol. 2024 Oct;43(10):3055-3072. doi: 10.1007/s10067-024-07123-y. Epub 2024 Aug 29.
6
Immune checkpoint inhibitor therapy in patients with cancer and pre-existing systemic sclerosis.癌症合并系统性硬化症患者的免疫检查点抑制剂治疗。
Semin Arthritis Rheum. 2024 Aug;67:152460. doi: 10.1016/j.semarthrit.2024.152460. Epub 2024 May 4.
7
Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study.血清 IL-17 和 TNFα 作为系统性硬化症患者的预后生物标志物：一项前瞻性研究。
Rheumatol Int. 2024 Jan;44(1):119-128. doi: 10.1007/s00296-023-05499-9. Epub 2023 Dec 5.
8
Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database.免疫检查点抑制剂与硬皮病：来自欧洲药物警戒数据库的数据
Drugs Real World Outcomes. 2024 Mar;11(1):33-41. doi: 10.1007/s40801-023-00399-7. Epub 2023 Oct 31.
9
Oral Submucous Fibrosis and Scleroderma: A Review of the Etiopathogenesis, Clinicopathological Correlation, and Management Aspects.口腔黏膜下纤维化与硬皮病：病因发病机制、临床病理相关性及治疗方面的综述
Cureus. 2023 Aug 31;15(8):e44502. doi: 10.7759/cureus.44502. eCollection 2023 Aug.
10
Critical digital ischaemia in systemic sclerosis exacerbated by multiple myeloma: A case report.多发性骨髓瘤加重系统性硬化症中的严重手指缺血：一例报告。
J Scleroderma Relat Disord. 2023 Oct;8(3):NP9-NP13. doi: 10.1177/23971983231171248. Epub 2023 Apr 28.
本文引用的文献
1
Scleroderma-like syndrome associated with pembrolizumab.与帕博利珠单抗相关的硬皮病样综合征。
J Scleroderma Relat Disord. 2020 Jun;5(2):NP5-NP6. doi: 10.1177/2397198320905192. Epub 2020 Feb 18.
2
The relationships between cancer and autoimmune rheumatic diseases.癌症与自身免疫性风湿病之间的关系。
Best Pract Res Clin Rheumatol. 2020 Feb;34(1):101472. doi: 10.1016/j.berh.2019.101472. Epub 2020 Feb 3.
3
Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review.与免疫检查点抑制剂相关的肢端血管坏死：病例报告并文献复习。
BMC Cancer. 2019 May 14;19(1):449. doi: 10.1186/s12885-019-5661-x.
4
Protective Effect Against Cancer of Antibodies to the Large Subunits of Both RNA Polymerases I and III in Scleroderma.抗体对 RNA 聚合酶 I 和 III 大亚基的保护作用可预防硬皮病患者发生癌症。
Arthritis Rheumatol. 2019 Sep;71(9):1571-1579. doi: 10.1002/art.40893. Epub 2019 Aug 1.
5
Scleroderma-like syndrome associated with nivolumab treatment in malignant melanoma.与纳武单抗治疗恶性黑色素瘤相关的硬皮病样综合征。
J Dermatol. 2019 Jan;46(1):e43-e44. doi: 10.1111/1346-8138.14492. Epub 2018 Jun 4.
6
Scleroderma-like skin changes induced by checkpoint inhibitor therapy.检查点抑制剂疗法诱发的硬皮病样皮肤改变
J Cutan Pathol. 2018 Aug;45(8):615-618. doi: 10.1111/cup.13273. Epub 2018 Jun 12.
7
Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer.自身抗体和硬皮病表型定义了癌症高风险和低风险亚组。
Ann Rheum Dis. 2018 Aug;77(8):1179-1186. doi: 10.1136/annrheumdis-2018-212999. Epub 2018 Apr 20.
8
Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients With Breast Cancer.放疗对硬皮病患者乳腺癌患者中硬皮病和癌症结局的影响。
Arthritis Care Res (Hoboken). 2018 Oct;70(10):1517-1524. doi: 10.1002/acr.23505.
9
Mechanistic and clinical insights at the scleroderma-cancer interface.硬皮病与癌症交叉领域的机制及临床见解。
J Scleroderma Relat Disord. 2017 Sep-Dec;2(3):153-159. doi: 10.5301/jsrd.5000250. Epub 2017 Oct 5.
10
Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease.无风湿性疾病的乳腺癌患者中癌症相关肌炎和硬皮病自身抗体的评估
Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):71-74. Epub 2017 Jun 19.
Zotero 插件