Dik Susamber, Özden Güzin, Cevirme Leyla, Erkoc Merve, Basir Hakan
Allergy and Immunology, Adana City Training and Research Hospital, Adana, TUR.
Cureus. 2025 Feb 18;17(2):e79259. doi: 10.7759/cureus.79259. eCollection 2025 Feb.
Multiple drug hypersensitivity syndrome (MDHS) is a rare condition characterized by hypersensitivity reactions to at least two chemically unrelated drugs. While non-steroidal anti-inflammatory drugs and antibiotics are the most commonly implicated agents, hypersensitivity to antihistamines is extremely rare. A comprehensive approach, including detailed patient history, skin testing, and drug provocation tests, is essential for the accurate diagnosis and management of MDHS, particularly in patients with multiple drug reactions. When evaluating MDHS, antihistamines should also be considered as potential culprits if suggested by the patient's history. Here, we aimed to present a case of a patient who reported allergic reactions following the administration of diclofenac sodium, paracetamol, COVID-19 mRNA vaccine, clarithromycin, and pheniramine hydrogen maleate. Based on the skin and provocation tests we performed, the patient was diagnosed with multiple drug hypersensitivity along with pheniramine allergy.
多种药物超敏反应综合征（MDHS）是一种罕见疾病，其特征为对至少两种化学结构不相关的药物发生超敏反应。虽然非甾体抗炎药和抗生素是最常涉及的药物，但对抗组胺药过敏极为罕见。全面的方法，包括详细的患者病史、皮肤试验和药物激发试验，对于MDHS的准确诊断和管理至关重要，尤其是对于有多种药物反应的患者。在评估MDHS时，如果患者病史提示，抗组胺药也应被视为潜在的病因。在此，我们旨在介绍一例患者，该患者在服用双氯芬酸钠、对乙酰氨基酚、新冠病毒mRNA疫苗、克拉霉素和马来酸氯苯那敏后出现过敏反应。根据我们进行的皮肤和激发试验，该患者被诊断为多种药物超敏反应以及对氯苯那敏过敏。
