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慢性硬膜下血肿的血管内栓塞治疗:当前证据的文献综述

Endovascular Embolization for Chronic Subdural Hematomas: A Literature Review of the Current Evidence.

作者信息

Estrella López Andrés Sebastián, Espin Jiménez Naomi Pauleth, Montalvo Ramos Patricio Alejandro, Castillo López Gabriela Alejandra

机构信息

Public Health, NeoScientia Consulting Group, Quito, ECU.

Rural Health, Ministerio de Salud Pública del Ecuador, Puyo, ECU.

出版信息

Cureus. 2025 Mar 20;17(3):e80898. doi: 10.7759/cureus.80898. eCollection 2025 Mar.

Abstract

Chronic subdural hematoma (cSDH) primarily affects elderly patients along with those who have multiple health problems, while it develops when blood collects between the dura mater and the brain. The condition results in substantial disability while also causing surgical treatment failures in certain cases. The occurrence of cSDH becomes more frequent as people age beyond 65 years old, which establishes this condition as a major health issue. The standard surgical evacuation method for treating this condition shows limited success because patients experience frequent recurrences, which motivates researchers to study endovascular embolization as an alternative treatment option. The promising endovascular embolization technique uses middle meningeal artery (MMA) embolization to target the blood supply of the neo-membrane surrounding the hematoma, thus preventing rebleeding and reducing recurrence. The available data shows that embolization of the MMA leads to better recurrence prevention than conventional surgical procedures among patients who face restrictions for surgery because of multiple health issues. The review analyzes current research about MMA embolization safety together with its effectiveness and appropriate applications for cSDH treatment. The existing evidence about endovascular embolization as adjunctive therapy to surgical procedures such as burr hole drainage or craniotomy provides a significant impact over standalone treatment for complex and recurrent cSDH cases, reducing recurrence, rescue rates, and complications. However, endovascular embolization also shows better clinical outcomes in reducing these outcomes, but for less complex cSDH cases. There is unclear or inconclusive evidence for overall cSDH patients because current research lacks large multicenter randomized controlled studies together with stringent quality standards and contains various patient groups and minimal study durations. The procedure's effectiveness remains unclear because researchers have not determined the best patient selection criteria, the most suitable embolic agent, or the most economical approach.

摘要

慢性硬膜下血肿(cSDH)主要影响老年患者以及患有多种健康问题的人群,它是在硬脑膜和脑之间积血时形成的。这种疾病会导致严重残疾,在某些情况下还会导致手术治疗失败。随着人们年龄超过65岁,cSDH的发生率会更高,这使其成为一个重大的健康问题。治疗这种疾病的标准手术引流方法成功率有限,因为患者经常复发,这促使研究人员研究血管内栓塞作为一种替代治疗选择。有前景的血管内栓塞技术利用脑膜中动脉(MMA)栓塞来针对血肿周围新膜的血液供应,从而防止再出血并减少复发。现有数据表明,对于因多种健康问题而面临手术限制的患者,MMA栓塞在预防复发方面比传统手术程序效果更好。该综述分析了当前关于MMA栓塞安全性及其对cSDH治疗的有效性和适当应用的研究。关于血管内栓塞作为钻孔引流或开颅手术等外科手术辅助治疗的现有证据,对复杂和复发性cSDH病例的单独治疗产生了重大影响,降低了复发率、抢救率和并发症。然而,血管内栓塞在减少这些结果方面也显示出更好的临床效果,但对于不太复杂的cSDH病例。对于总体cSDH患者,证据不明确或无定论,因为当前研究缺乏大型多中心随机对照研究以及严格的质量标准,并且包含各种患者群体且研究持续时间最短。该手术的有效性仍不明确,因为研究人员尚未确定最佳的患者选择标准、最合适的栓塞剂或最经济的方法。

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