Albin M S, Bunegin L, Wolf S
Surg Neurol. 1985 Aug;24(2):191-205. doi: 10.1016/0090-3019(85)90185-5.
The early physiopathologic responses to transection of the cervical spinal cord (C-4) were studied in the experimental animal. After transection, increases were seen in the mean arterial pressure, pulmonary capillary wedge pressure, intracranial pressure, brain water, blood--brain barrier permeability, and extravascular lung water with a marked decrease occurring in cerebral blood flow. Pretreatment with an alpha-adrenergic blocker, phentolamine (Regitine Ciba-Geigy Corp.), followed by transection blocked the rise in mean arterial blood pressure and pulmonary capillary wedge pressure but did not affect the increases in intracranial pressure, brain water, blood--brain barrier permeability, and extravascular lung water and decreases in cerebral blood flow. Transection of the cervical spinal cord initiates a complex series of events involving intracranial compliance and pulmonary permeability, placing both brain and lungs at risk.
在实验动物中研究了颈髓（C - 4）横断后的早期病理生理反应。横断后，平均动脉压、肺毛细血管楔压、颅内压、脑含水量、血脑屏障通透性和血管外肺水增加，而脑血流量显著减少。用α - 肾上腺素能阻滞剂酚妥拉明（瑞支亭，汽巴 - 嘉基公司）预处理后再进行横断，可阻止平均动脉血压和肺毛细血管楔压升高，但不影响颅内压、脑含水量、血脑屏障通透性和血管外肺水的增加以及脑血流量的减少。颈髓横断引发了一系列涉及颅内顺应性和肺通透性的复杂事件，使脑和肺都处于危险之中。
