Lazar Dragos Stefan, Gherlan George Sebastian, Florescu Simin Aysel, Popescu Corneliu Petru, Nica Maria
Infectious Diseases Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Infectious Diseases Department, Dr. Victor Babes Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania.
Infect Dis Rep. 2025 Feb 25;17(2):16. doi: 10.3390/idr17020016.
BACKGROUND/OBJECTIVES: Although a "forgotten" disease in developed countries, typhoid fever remains a significant global health problem, especially in regions with inadequate sanitation and overcrowding. Despite medical advances, this systemic bacterial infection, caused by Typhi, continues to affect millions worldwide. Accurate diagnosis and timely treatment are crucial to prevent severe complications and mortality. Even though antibiotic therapy is effective, the emergence of drug-resistant strains is a growing challenge.
We present a series of cases encountered in a tertiary infectious disease hospital in Romania over 15 years.
The hospitalised patients were mainly from Sub-Saharan Africa and the Indian subcontinent; the median time between the onset of the first symptoms and hospital admission was 15 days. The symptoms encountered along with fever were headache, chills, cough, diarrhoea and tachycardia, an unusual feature in the clinical picture of this disease. Aneosinophilia (the absence of peripheral eosinophilic granulocytes) was the most frequently encountered laboratory finding, followed by increased serum transaminases and inflammatory syndrome.
. Typhi was generally identified from blood culture, demonstrating, except in one case, resistance to ciprofloxacin and, in several cases, multi-drug resistance (MDR). In this series of cases, all strains were sensitive to ceftriaxone.
背景/目的：伤寒热在发达国家虽属“被遗忘的”疾病，但仍是一个重大的全球健康问题，尤其是在卫生条件差和人口密集的地区。尽管医学取得了进展，但这种由伤寒杆菌引起的全身性细菌感染仍在全球影响着数百万人。准确诊断和及时治疗对于预防严重并发症和死亡至关重要。尽管抗生素治疗有效，但耐药菌株的出现是一个日益严峻的挑战。
我们介绍了罗马尼亚一家三级传染病医院15年来遇到的一系列病例。
住院患者主要来自撒哈拉以南非洲和印度次大陆；首次出现症状到入院的中位时间为15天。除发热外，还出现头痛、寒战、咳嗽、腹泻和心动过速等症状，这在该疾病的临床症状中是不常见的特征。嗜酸性粒细胞缺乏（外周嗜酸性粒细胞缺失）是最常见的实验室检查结果，其次是血清转氨酶升高和炎症综合征。
伤寒杆菌通常通过血培养鉴定，除1例病例外，均显示对环丙沙星耐药，在几例病例中显示多重耐药（MDR）。在这一系列病例中，所有菌株对头孢曲松均敏感。
