Lee G, Chan M C, Seckinger D L, Vazquez A, Rosenthal P K, Lee K K, Ikeda R M, Reis R L, Hanna E S, Mason D T
Thromb Res. 1985 Jun 1;38(5):561-5. doi: 10.1016/0049-3848(85)90188-4.
Since argon laser radiation (454-514 nm) can vaporize human clots, we determined whether the absorption of laser energies can differ among different types of blood clots. Thus we performed spectrophotometric studies and examined the ability of this laser to penetrate red cell rich and red cell poor clots. Fifty-four red cell rich and red cell poor clot samples, varying in depth from 1.8 to 5.0 mm, were subjected to 3, 5 and 7 watts from an argon laser beam. At a given power intensity, the deeper the red cell rich clot, the longer was the time needed to penetrate the clot. The higher the power used, the shorter was the red clot penetration time. In contrast, all power levels used up to 5 minutes did not penetrate any of the varying depths of red cell poor clots. Spectrophotometrically, the red cell rich clot had an absorption curve typical of hemoglobin pigment while the red cell poor clot, in the absence of hemoglobin, had poor absorption between 350 and 600 nm and was unable to absorb argon laser energies. Thus, the argon laser provides a therapeutic modality for human red cell rich clot dissolution but the present approach does not appear to be effective against red cell poor clots.
由于氩激光辐射（454 - 514纳米）能使人体血凝块汽化，我们确定了不同类型血凝块对激光能量的吸收是否存在差异。因此，我们进行了分光光度研究，并检测了这种激光穿透富含红细胞和贫红细胞血凝块的能力。对54个深度在1.8至5.0毫米之间的富含红细胞和贫红细胞的血凝块样本，用氩激光束分别给予3瓦、5瓦和7瓦的能量。在给定的功率强度下，富含红细胞的血凝块越深，穿透血凝块所需的时间就越长。使用的功率越高，红色血凝块的穿透时间就越短。相比之下，在长达5分钟的时间内，所有功率水平都无法穿透不同深度的贫红细胞血凝块。分光光度研究表明，富含红细胞的血凝块具有典型的血红蛋白色素吸收曲线，而贫红细胞血凝块在没有血红蛋白的情况下，在350至600纳米之间吸收较差，无法吸收氩激光能量。因此，氩激光为溶解人体富含红细胞的血凝块提供了一种治疗方式，但目前的方法对贫红细胞血凝块似乎无效。
