环己烷环氧化物衍生物在沙门氏菌试验中的致突变性。
Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives.
作者信息
Frantz S W, van den Eeckhout E, Sinsheimer J E, Yoshihara M, Koreeda M
出版信息
Toxicol Lett. 1985 Jun;25(3):265-71. doi: 10.1016/0378-4274(85)90206-1.
15 Cyclohexane epoxide derivatives were synthesized and compared for direct mutagenicity and bacterial toxicity using Salmonella typhimurium strain TA100 in the liquid suspension and spot-test version of the Ames procedure. While no general correlations could be established for position and stereochemistry of the hydroxylated derivatives, an increase in mutagenicity was noted for the presence of electron-withdrawing groups and unsaturation in conjugation with the oxirane groups.
合成了15种环己烷环氧化物衍生物，并使用鼠伤寒沙门氏菌TA100菌株，通过Ames试验的液体悬浮液和点试验版本，比较了它们的直接致突变性和细菌毒性。虽然对于羟基化衍生物的位置和立体化学无法建立普遍的相关性，但发现吸电子基团的存在以及与环氧乙烷基团共轭的不饱和键会增加致突变性。
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