Lee Dong Ah, Ko Junghae, Park Bong Soo, Park Kang Min
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Department of Internal medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Medicine (Baltimore). 2025 Mar 21;104(12):e41886. doi: 10.1097/MD.0000000000041886.
This study aimed to investigate the alterations in the intrinsic thalamic network in patients with poststroke epilepsy (PSE) based on electroencephalography (EEG) source-level analysis. This retrospective observational study followed the STROBE guidelines. Thirty-nine patients with stroke and PSE and 34 patients with stroke without PSE were enrolled. These patients underwent EEG in a resting state. Source localization based on scalp electrical potentials was computed using the minimum norm imaging method and the standardized low-resolution brain electromagnetic tomography approach. To construct a functional connectivity matrix, the Talairach atlas was used to define the nodes belonging to the thalamus, and the coherence method was applied to measure brain synchronization as edges. The intrinsic thalamic network was analyzed using graph theory and compared between patients with and without PSE. EEG source-level analysis revealed notable differences in the intrinsic thalamic network between patients with and without PSE. From the undirected weighted connectivity matrix, the measure of modularity was lower in patients with PSE than in those without PSE (0.038 vs 0.106, P = .024). Additionally, modularity measures showed significant differences between the groups, as demonstrated by graph theoretical analysis using binary undirected graphs with a fixed density range of connections. This study is the first to demonstrate the alterations in the intrinsic thalamic network in patients with stroke with PSE compared to those without PSE based on EEG source-level analysis. These intrinsic thalamic network changes may be related to PSE development.
本研究旨在基于脑电图（EEG）源水平分析，调查卒中后癫痫（PSE）患者丘脑固有网络的改变。这项回顾性观察研究遵循了STROBE指南。纳入了39例患有卒中和PSE的患者以及34例患有卒中但无PSE的患者。这些患者在静息状态下接受了脑电图检查。基于头皮电位的源定位使用最小范数成像方法和标准化低分辨率脑电磁断层扫描方法进行计算。为构建功能连接矩阵，使用Talairach图谱定义属于丘脑的节点，并应用相干方法测量脑同步作为边。使用图论分析丘脑固有网络，并在有和无PSE的患者之间进行比较。EEG源水平分析显示，有和无PSE的患者在丘脑固有网络方面存在显著差异。从未加权连接矩阵来看，PSE患者的模块化度量低于无PSE的患者（0.038对0.106，P = 0.024）。此外，模块化度量在两组之间显示出显著差异，这通过使用固定连接密度范围的二元无向图进行图论分析得到了证明。本研究首次基于EEG源水平分析证明了患有PSE的卒中患者与无PSE的卒中患者相比，丘脑固有网络存在改变。这些丘脑固有网络变化可能与PSE的发生有关。
