一种用于测试化疗药物对肾腺癌有效性的新型动物模型。
A new animal model for testing the effectiveness of chemotherapeutic agents on renal adenocarcinoma.
作者信息
White R D, Previte S, Olsson C A
机构信息
Department of Urology, Boston University School of Medicine, Boston.
出版信息
Surg Forum. 1978;29:629-31.
PMID:401284
Abstract
A renal cell endocarcinoma that arose spontaneously in a Wistar-Lewis rat has been used to screen various chemotherapeutic agents for effectiveness against this tumor. Of the agents so far tested, cyclophosphamide (Cytoxan) and vinblastine have displayed very considerable anti-tumor activity. Adriamycin was marginal, and fluorouracil (5-FU) and Cis-dichlorodiammine Platinum (II) were ineffective.
摘要
一只自发发生肾细胞癌的Wistar-Lewis大鼠被用于筛选各种化疗药物对该肿瘤的有效性。在迄今为止测试的药物中，环磷酰胺（癌得星）和长春碱显示出非常可观的抗肿瘤活性。阿霉素效果一般，而氟尿嘧啶（5-FU）和顺式二氯二氨铂（II）无效。
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