Granato Alberto
Department of Veterinary Sciences, University of Turin, Grugliasco, TO, Italy.
Adv Exp Med Biol. 2025;1473:3-13. doi: 10.1007/978-3-031-81908-7_1.
The interplay between excitatory pyramidal neurons and GABAergic interneurons is the basic building block of neocortical microcircuits and plays a critical role in carrying out higher cognitive functions. Cortical circuits are deeply and permanently disrupted by exposure to alcohol during brain development, the main non-genetic cause of intellectual disability. Here, I review experimental studies of fetal alcohol spectrum disorders, dealing with permanent cellular and molecular alterations of neocortical neurons and their connections.
兴奋性锥体神经元和γ-氨基丁酸能中间神经元之间的相互作用是新皮层微回路的基本组成部分，在执行高级认知功能中起着关键作用。在大脑发育过程中接触酒精会严重且永久性地破坏皮层回路，酒精是智力残疾的主要非遗传原因。在此，我回顾了胎儿酒精谱系障碍的实验研究，这些研究涉及新皮层神经元及其连接的永久性细胞和分子改变。
