Pandey Neha, Singh Sunit K
Molecular Biology Unit, Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Dr. B R Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi, India.
Rev Med Virol. 2025 Mar;35(2):e70032. doi: 10.1002/rmv.70032.
Chandipura virus (CHPV) is a single-stranded negative-sense RNA virus of the family Rhabdoviridae. CHPV is transmitted mainly through infected sandflies. CHPV paediatric encephalitis reported in 2003-2004 in central and south-western parts of India had a case fatality rate of ∼70%. CHPV infection leads to high-grade fever, vomiting, altered sensorium, generalised convulsions, decerebrate posture and coma. Neuroinflammation is the hallmark of CHPV infection and has a pronounced effect on cerebral and brainstem regions. Currently, there are no vaccines or treatments available for CHPV infection. Although previous studies have provided insights into the virus's pathology and host-pathogen interactions, the precise molecular mechanisms underlying CHPV pathogenesis are poorly understood. Understanding molecular pathogenesis is crucial for developing efficacious therapies and preventive measures. The review summarises CHPV epidemiology, transmission, genome structure, replication, pathogenesis and the latest antiviral therapies and vaccine developments.
钱迪普拉病毒（CHPV）是弹状病毒科的一种单链负义RNA病毒。CHPV主要通过受感染的白蛉传播。2003年至2004年在印度中部和西南部报告的CHPV小儿脑炎病死率约为70%。CHPV感染会导致高热、呕吐、意识改变、全身惊厥、去大脑强直姿势和昏迷。神经炎症是CHPV感染的标志，对大脑和脑干区域有显著影响。目前，尚无针对CHPV感染的疫苗或治疗方法。尽管先前的研究对该病毒的病理学和宿主-病原体相互作用提供了见解，但对CHPV发病机制的精确分子机制了解甚少。了解分子发病机制对于开发有效的治疗方法和预防措施至关重要。本综述总结了CHPV的流行病学、传播、基因组结构、复制、发病机制以及最新的抗病毒治疗和疫苗研发情况。
