英国纵向关联合作组织（UK LLC）：纵向研究的国家可信研究环境。

UK Longitudinal Linkage Collaboration (UK LLC): The National Trusted Research Environment for Longitudinal Research.

作者信息

Boyd Andy, Evans Katharine M, Turner Emma L, Flaig Robin, Oakley Jacqui, Campbell Kirsteen C, Thomas Richard, McLachlan Stela, Crane Matthew, Whitehorn Rebecca, Calkin Rachel, Hill Abigail, Berman Samantha, Ford David, Tobin Martin, Porteous David, Gomes Danielle F, Garcia Maria-Paz, Wong Andrew, Sanchez Aida, Orton Chris, Thompson Simon, Gulliver John, Adams Kathryn, Badrick Ellena, Batini Chiara, Benzeval Michaela, Boatman Susie, Breen Gerome, Bristow Shannon, Britten Abigail, Bryant Luke, Butterworth Adam, Campbell Archie, Chave Sarah, Danesh John, Das-Munshi Jayati, Dennison Karen, Angelantonio Emanuele Di, Eley Thalia C, Fisher Helen, Fitzsimons Emla, Goodman Alissa, Gregg Michael, Guyatt Anna L, Hansell Anna, Harmston Rebecca, Heard Andy, Henderson Morag, Hill Rosie, Huang Szu-Chia, John Catherine, Kee Frank, Kingston Nathalie, Kneeshaw Jack, Kumar Rashmi, Lachance Genevieve, Lockhart Celestine, Lockhart-Jones Hazel, Markham Sarah, Mason Dan, McGuinness Bernadette, McKenzie Maisie, McMahon Amy, Malouf Chelsea Mika, Mumme Mark, Neville Charlotte, Northstone Kate, Oldfield Zoe, O'Neill Dara, Pareek Manish, Pickavance John, Rahman Yasmin, Reilly Holly, Scott Angela, Smith Deb, Steptoe Andrew, Steves Claire, Sudlow Cathie, Sze Gerald, Timpson Nicholas L, Tungamirai Tapiwa, Venn Laura, Walker Matthew, Walker Neil, Wareham Nicolas, Watmuff Aidan, Webb Tony, Williams Karen, Wright John, Yarand Darioush, Ploubidis George B, Macleod John, Sterne Jonathan Ac, Chaturvedi Nishi

机构信息

UK Longitudinal Linkage Collaboration, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PS, UK.

Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

出版信息

Int J Popul Data Sci. 2025 Feb 17;10(1):2468. doi: 10.23889/ijpds.v10i1.2468. eCollection 2025.

DOI:10.23889/ijpds.v10i1.2468

PMID:40129687

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11931487/

Abstract

INTRODUCTION

The UK Longitudinal Linkage Collaboration (UK LLC) is the national Trusted Research Environment (TRE) for the UK's longitudinal research community, supporting the UK's unparalleled collection of Longitudinal Population Studies (LPS). Initially set up as a COVID-19 research resource, UK LLC is now a generic database for any research for the public good.

OBJECTIVES

UK LLC supports longitudinal research by providing record linkage and TRE services.

METHODS

The UK LLC partnership provides a secure analytics environment, a trusted third-party linkage processor and a comprehensive governance framework to minimise risks to participant confidentiality. UK LLC is ISO 27001 certified and accredited by the UK Statistics Authority as a processor under the Digital Economy Act. The active involvement by members of UK LLC's public involvement programme ensures UK LLC is acceptable to LPS participants and the wider public. All UK LPS are eligible for inclusion. Researchers can apply to access the TRE via an approach that fulfils the needs of the LPS, the linked data owners and includes a review by public contributors.

RESULTS

Twenty-two LPS have so far joined UK LLC. Where permissions allow, participants are linked to their National Health Service (NHS) England, NHS Wales and place-based records, with work ongoing to link to NHS Scotland and non-health administrative records, including Department for Work and Pensions and His Majesty's (HM) Revenue and Customs. UK LLC Explore allows potential researchers to discover the breadth of data available in the TRE. All applications are listed on UK LLC's publicly accessible Data Access Register.

CONCLUSIONS

UK LLC enables researchers to interrogate pooled LPS participant data that are systematically linked to diverse records. UK LLC remains open to additional LPS joining the partnership and will increase the breadth of data to support the longitudinal research community and attract increasing numbers of researchers across multiple disciplines, government departments and industry.

摘要

引言

英国纵向关联协作组织（UK LLC）是英国纵向研究领域的国家可信研究环境（TRE），支持英国无与伦比的纵向人口研究（LPS）集合。UK LLC最初是作为新冠疫情研究资源设立的，现在是一个用于任何公益研究的通用数据库。

目标

UK LLC通过提供记录关联和TRE服务来支持纵向研究。

方法

UK LLC合作伙伴关系提供了一个安全的分析环境、一个可信的第三方关联处理机构以及一个全面的治理框架，以将对参与者保密性的风险降至最低。UK LLC通过了ISO 27001认证，并被英国统计局认可为《数字经济法案》下的处理机构。UK LLC公众参与计划成员的积极参与确保了UK LLC为LPS参与者和更广泛的公众所接受。所有英国的LPS都有资格被纳入。研究人员可以通过一种满足LPS、关联数据所有者需求并包括公众贡献者审查的方式申请访问TRE。

结果

到目前为止，已有22个LPS加入了UK LLC。在许可允许的情况下，参与者与他们在英格兰国民医疗服务体系（NHS）、威尔士NHS以及基于地点的记录相链接，目前正在努力与苏格兰NHS和非健康行政记录相链接，包括工作和养老金部以及英国税务海关总署的记录。UK LLC Explore使潜在研究人员能够发现TRE中可用数据的广度。所有申请都列在UK LLC可公开访问的数据访问登记册上。