儿童类鼻疽继发噬血细胞性淋巴组织细胞增生症：病例系列
Hemophagocytic Lymphohistiocytosis Secondary to Melioidosis in Paediatric Patients: A Case Series.
作者信息
Wan Kecheng, Liu Yingjie, Chen Yuwen, Sun Song, Liang Hong
机构信息
Department of Paediatrics, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
出版信息
Infect Drug Resist. 2025 Mar 19;18:1561-1566. doi: 10.2147/IDR.S505259. eCollection 2025.
BACKGROUND
Melioidosis caused by manifests as a variety of infectious symptoms. However, hemophagocytic lymphohistiocytosis (HLH) secondary to bacteraemic melioidosis is rarely documented in the literature. We report a series of fatal cases of melioidosis combined with HLH in one Chinese family.
CASE PRESENTATION
Three cases of melioidosis with HLH were reported in a family with three children, two boys aged 4 and 6 years and a 12-year-old girl. The most common clinical presentation was fever. A blood culture confirmed , and bone marrow aspiration revealed hemophagocytosis. Despite the administration of antibiotics, glucocorticoids and other treatments, all the patients died, and their deaths were attributed to HLH.
CONCLUSION
Melioidosis complicating HLH is rare in occurrence, but the mortality rate is high. Clinicians should be aware of the risk of a bloodstream infection in children.
背景
由[病原体未提及]引起的类鼻疽病表现为多种感染症状。然而，文献中很少记载菌血症性类鼻疽病继发噬血细胞性淋巴组织细胞增生症（HLH）的情况。我们报告了一个中国家庭中一系列类鼻疽病合并HLH的致命病例。
病例报告
一个有三个孩子的家庭中报告了三例类鼻疽病合并HLH的病例，两个男孩分别为4岁和6岁，一个女孩为12岁。最常见的临床表现是发热。血培养证实了[病原体未提及]，骨髓穿刺显示噬血细胞现象。尽管给予了抗生素、糖皮质激素和其他治疗，但所有患者均死亡，其死亡归因于HLH。
结论
类鼻疽病合并HLH的发生率很低，但死亡率很高。临床医生应意识到儿童发生[病原体未提及]血流感染的风险。
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