Chen Xia, Qin Yang, Gan Jinfeng, Wei Tangwen, Wei Xinyi, Xiong Yaling, Zhang Zhichang, Wei Bing
Department of Geriatrics, Affiliated Hospital of Guilin Medical University, Guilin, China.
Department of Rheumatology and immunology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Hum Vaccin Immunother. 2025 Dec;21(1):2483558. doi: 10.1080/21645515.2025.2483558. Epub 2025 Mar 25.
Recently, immunotherapy has been a key therapeutic strategy for cancer. Deubiquitinating enzymes (DUBs), which are protein-modifying enzymes, have a crucial role in the pathogenesis of cancer, autoimmune diseases, and inflammation. DUBs influence the tumor immune microenvironment by regulating immune cell functions and key signaling pathways. Thus, the potential applications of DUBs in immunotherapy have piqued the interest of the scientific community. This study performed bibliometric analysis to comprehensively examine the research hotspots and trends in this field, providing theoretical foundations and guidance for future research. Studies associated with DUBs and immunotherapy conducted over a decade (2014 to 2024) were searched and extracted from Web of Science Collection database. The analysis was performed using CiteSpace, VOSviewer, and the Bibliometrix package in R software. Visualizations were generated for countries, institutions, authors, journals, references, and keyword co-occurrences. In total, 321 articles related to DUBs and immunotherapy were retrieved. The number of publications increased markedly since 2020. China had the highest number of publications, while the United States exerted the most influence in this field. Zhang Jinfang was the most influential author in this field. Zhejiang University was the institution with the highest number of publications. Nature was the most cited journal (807 total citations). Keyword analysis revealed that the primary research hotspots were expression, immunotherapy, ubiquitination, degradation, and cancer. This bibliometric analysis revealed the research trends and emerging frontiers in DUBs and immunotherapy, offering novel strategies for the application of DUBs in immunotherapy.
近年来，免疫疗法已成为癌症治疗的关键策略。去泛素化酶（DUBs）作为蛋白质修饰酶，在癌症、自身免疫性疾病和炎症的发病机制中起着至关重要的作用。DUBs通过调节免疫细胞功能和关键信号通路来影响肿瘤免疫微环境。因此，DUBs在免疫疗法中的潜在应用引起了科学界的关注。本研究进行了文献计量分析，以全面审视该领域的研究热点和趋势，为未来研究提供理论基础和指导。检索并从Web of Science核心合集数据库中提取了过去十年（2014年至2024年）与DUBs和免疫疗法相关的研究。使用CiteSpace、VOSviewer和R软件中的Bibliometrix软件包进行分析。生成了关于国家、机构、作者、期刊、参考文献和关键词共现的可视化图表。总共检索到321篇与DUBs和免疫疗法相关的文章。自2020年以来，出版物数量显著增加。中国的出版物数量最多，而美国在该领域的影响力最大。张锦芳是该领域最具影响力的作者。浙江大学是出版物数量最多的机构。《自然》是被引用次数最多的期刊（总被引次数807次）。关键词分析表明，主要研究热点包括表达、免疫疗法、泛素化、降解和癌症。这项文献计量分析揭示了DUBs和免疫疗法的研究趋势及新兴前沿，为DUBs在免疫疗法中的应用提供了新策略。
