College of Traditional Chinese Medicine, Jiangsu College of Nursing, Huaian, Jiangsu, China.
Department of Clinical Pharmacy, Jinling Hospital, Medical school of Nanjing University, Nanjing, China.
Front Immunol. 2024 Aug 13;15:1433050. doi: 10.3389/fimmu.2024.1433050. eCollection 2024.
BACKGROUND: Cancer immunotherapy has made significant progress in recent years, with numerous studies worldwide. Immunotherapy has had a transformative impact on oncology and autoimmune diseases. In the biomedical arena, hydrogels with good properties are widely used in cancer immunotherapy. Our study used bibliometrics to analyze the changing trends in using hydrogels for cancer immunotherapy. METHODS: From 2013 to 2023, a systematic search was conducted in the Web of Science Core Collection database to identify reviews and articles discussing the applications of hydrogels in cancer immunotherapy. The software CiteSpace was used to visually perform the bibliometric analysis in terms of research trends, countries, institutions, authors, journals, and keywords. Individual authors' productivity was assessed with the Lotka's law. The most relevant publication sources were identified by Bradford's law. RESULTS: A total of 422 English-language publications related to hydrogels in cancer immunotherapy were collected. The number of annual publications increased rapidly after 2021 and remained constant for the past two years. China published the most articles in this field. The institution with the maximum number of published articles was the Chinese Academy of Sciences in China. Chen. Q was the most prolific author, and Liu. Z was the second most published author. In terms of journal contributions, the journal "Biomaterials" had the highest number of publications (n = 30). Biomaterials, Advanced Functional Materials and Journal of Controlled Release were the most influential journals. Keyword analysis revealed that cancer immunotherapy, drug delivery, immunogenic cell death, tumor microenvironment, injectable hydrogels, and immune checkpoint blockade were the primary research hotspots. In recent 3 years, adoptive T-cell therapy, black phosphorus, cell capture, adaptive cell therapy, tumor microenvironment, photodynamic therapy, and sustained release were the research hotspots in this field. Our study summarizes the objective of hydrogels in cancer immunotherapy in recent years, providing a reference for potential researchers in related field. CONCLUSION: This bibliometric analysis shows the progress and trend of research on hydrogels in cancer immunotherapy. This study provides a significant avenue for future investigation into current concerns and trends in research within this field.
背景:近年来,癌症免疫疗法在全球范围内取得了重大进展。免疫疗法对肿瘤学和自身免疫性疾病产生了变革性的影响。在生物医学领域,具有良好性能的水凝胶广泛应用于癌症免疫治疗。我们的研究使用文献计量学分析了使用水凝胶进行癌症免疫治疗的变化趋势。
方法:从 2013 年到 2023 年,在 Web of Science 核心合集数据库中进行了系统搜索,以确定讨论水凝胶在癌症免疫治疗中应用的综述和文章。使用 CiteSpace 软件从研究趋势、国家、机构、作者、期刊和关键词等方面进行了可视化的文献计量分析。使用洛特卡定律评估了单个作者的生产力。通过布拉德福定律确定了最相关的出版物来源。
结果:共收集到 422 篇与癌症免疫治疗中水凝胶相关的英文出版物。2021 年后,年度出版物数量迅速增加,近两年保持不变。中国在该领域发表的文章最多。发表文章数量最多的机构是中国科学院。陈 Q 是最具影响力的作者,刘 Z 是第二大发表作者。就期刊贡献而言,期刊《生物材料》发表的文章数量最多(n = 30)。生物材料、先进功能材料和控释杂志是最有影响力的期刊。关键词分析显示,癌症免疫治疗、药物输送、免疫原性细胞死亡、肿瘤微环境、可注射水凝胶和免疫检查点阻断是主要研究热点。在最近 3 年中,过继性 T 细胞治疗、黑磷、细胞捕获、适应性细胞治疗、肿瘤微环境、光动力治疗和持续释放是该领域的研究热点。本研究总结了近年来水凝胶在癌症免疫治疗中的目标,为相关领域的潜在研究人员提供了参考。
结论:这项文献计量分析展示了癌症免疫治疗中水凝胶研究的进展和趋势。本研究为未来研究该领域当前关注的问题和趋势提供了重要途径。
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