Zhang Shuai, Huang Ting, Lu Yun, Guo Xi, Shang Quanliang
Wu Zhong People's Hospital, Wuzhong, Ningxia, People's Republic of China.
The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Sci Rep. 2025 Mar 25;15(1):10228. doi: 10.1038/s41598-025-91859-3.
To investigate the dynamic changes in multiple planes and parameters of the aortic root region at different phases of the cardiac cycle in patients with aortic regurgitation (AR) using multi-detector row computed tomography (MDCT). To provide more reference information and research foundation for preoperative MDCT evaluation of patients with aortic regurgitation undergoing Transcatheter Aortic Valve Replacement (TAVR).
Using MDCT, measurements were taken at the aortic annulus (AA), left ventricular outflow tract (LVOT), and sinotubular junction (STJ) during different phases of the cardiac cycle, including early systole, late systole, early diastole, and late diastole. The analyzed parameters included area, perimeter, diameter derived from area (DA), diameter derived from circumference (DC), long axis, short axis, and average diameter at each phase for each location. The dynamic changes in these parameters were then analyzed.
At the AA, the early systolic area, perimeter, DA, DC, and average diameter reached their maximum values, which were significantly greater than those in early diastole (P < 0.05). At the LVOT, the morphological parameters including area, perimeter, DC, DA, and long diameter reached their maximum values in late diastole, with no significant differences compared to early or late systole (P > 0.05). However, significant differences were observed between late diastole and early diastole (P < 0.05).At the STJ, the area, perimeter, DA, DC, long diameter, short diameter, and average diameter reached their maximum values in late systole, but there were no significant differences compared to early systole or early diastole (P > 0.05), while the difference from late diastole was significant (P < 0.05).
In patients with AR, the measurement parameters of the AA、LVOT and the STJ are critical for the success of TAVR.Preoperative prosthesis selection for TAVR can still be based on MDCT measurements taken during early systole at the AA.
使用多排螺旋计算机断层扫描（MDCT）研究主动脉瓣反流（AR）患者在心动周期不同阶段主动脉根部区域多个平面和参数的动态变化。为接受经导管主动脉瓣置换术（TAVR）的主动脉瓣反流患者术前MDCT评估提供更多参考信息和研究基础。
使用MDCT在心动周期的不同阶段，包括收缩早期、收缩晚期、舒张早期和舒张晚期，对主动脉瓣环（AA）、左心室流出道（LVOT）和窦管交界（STJ）进行测量。分析的参数包括每个位置在每个阶段的面积、周长、面积衍生直径（DA）、周长衍生直径（DC）、长轴、短轴和平均直径。然后分析这些参数的动态变化。
在AA处，收缩早期的面积、周长、DA、DC和平均直径达到最大值，显著大于舒张早期（P < 0.05）。在LVOT处，包括面积、周长、DC、DA和长径在内的形态学参数在舒张晚期达到最大值，与收缩早期或晚期相比无显著差异（P > 0.05）。然而，舒张晚期与舒张早期之间存在显著差异（P < 0.05）。在STJ处，面积、周长、DA、DC、长径、短径和平均直径在收缩晚期达到最大值，但与收缩早期或舒张早期相比无显著差异（P > 0.05），而与舒张晚期的差异显著（P < 0.05）。
在AR患者中，AA、LVOT和STJ的测量参数对TAVR的成功至关重要。TAVR术前假体选择仍可基于AA处收缩早期的MDCT测量。
