Zielinski C C, Kuzmits R, Kubista E, Salzer H, Staffen A, Aiginger P, Spona J
Wien Klin Wochenschr. 1985 May 24;97(11):493-7.
The importance of the presence of hormone receptors of cells derived from breast cancer tissue for the duration of the relapse-free interval was evaluated in 41 patients with stage II breast cancer. After modified radical mastectomy with axillary lymphadenectomy the patients received radiotherapy and adjuvant polychemotherapy and/or hormone therapy. There was no indication of metastases in any patient at the time of operation. There was a significant correlation of the relapse-free interval to tumor size (p less than 0.05), to the number of involved lymph nodes (p less than 0.0005), and also to the presence of the progesterone receptor (PgR), which seemed to play a more important role in this context than the oestrogen receptor (ER) (p less than 0.001). We conclude from this study that the evaluation of the PgR in breast cancer cells is important for the prognosis of the duration of the relapse-free interval.
对41例II期乳腺癌患者评估了源自乳腺癌组织的细胞中激素受体的存在对无复发生存期的重要性。在改良根治性乳房切除术加腋窝淋巴结清扫术后，患者接受了放疗和辅助多药化疗及/或激素治疗。手术时任何患者均无转移迹象。无复发生存期与肿瘤大小（p<0.05）、受累淋巴结数量（p<0.0005）以及孕激素受体（PgR）的存在均有显著相关性，在这种情况下，PgR似乎比雌激素受体（ER）发挥更重要的作用（p<0.001）。我们从这项研究得出结论，评估乳腺癌细胞中的PgR对无复发生存期的预后很重要。
