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黄酒所致急性草酸盐肾病:一例报告

Acute oxalate nephropathy due to yellow rice wine: a case report.

作者信息

Chen Xi, Shen Jie, Liu Yuxue, Ran Yingchun, Chen Mindong, Zhou Rong

机构信息

Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.

出版信息

BMC Nephrol. 2025 Mar 25;26(1):151. doi: 10.1186/s12882-025-04067-6.

Abstract

BACKGROUND

Acute oxalate nephropathy is a rare but potentially underrecognized cause of acute kidney injury (AKI). The reports of secondary oxalate nephropathy induced by high doses of vitamin C, portulaca oleracea, Peanut were described, but the cause as yellow wine consumption are rare. We report a 63-year-old man with acute kidney injury due to yellow rice wine. The patient has drunk yellow rice wine 500 mL/day for the past 10 years. He underwent an ultrasound-guided renal biopsy, which showed acute tubular injury and birefringent crystals were observed in the renal tubules under a polarizing microscope. The 24-hour urinary oxalate excretion established and the baseline serum creatinine of 407 µmol/L. Following 3 months therapy, subsequent laboratory evaluation demonstrated significant reduction in urinary oxalate excretion excretion and serum creatinine normal.

CONCLUSIONS

Acute secondary oxalate nephropathy due to excessive dietary intake of oxalate may lead to AKI. Kidney biopsies in unknown cause AKI patients is important and attention should be payed to food behaviors when reasons for AKI are explored.

摘要

背景

急性草酸盐肾病是急性肾损伤(AKI)的一种罕见但可能未被充分认识的病因。有关于高剂量维生素C、马齿苋、花生诱发继发性草酸盐肾病的报道,但因饮用黄酒导致的病例罕见。我们报告一例因饮用黄酒导致急性肾损伤的63岁男性患者。该患者在过去10年中每天饮用500毫升黄酒。他接受了超声引导下肾活检,结果显示急性肾小管损伤,在偏振显微镜下观察到肾小管内有双折射晶体。测定了24小时尿草酸盐排泄量,基线血清肌酐为407微摩尔/升。经过3个月的治疗,随后的实验室评估显示尿草酸盐排泄量显著降低,血清肌酐恢复正常。

结论

因饮食中草酸盐摄入过多导致的急性继发性草酸盐肾病可能会引发急性肾损伤。对病因不明的急性肾损伤患者进行肾活检很重要,在探究急性肾损伤病因时应关注其饮食行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6494/11934763/a33cf1999494/12882_2025_4067_Fig1_HTML.jpg

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