Kırbaş Zila Özlem, Bayraktar Bülent, Odabaşi Aktaş Elif
Department of Nursing, Bayburt University Faculty of Health Sciences, Bayburt, 69000, Türkiye.
Department of Physiotherapy and Rehabilitation, Bayburt University Faculty of Health Sciences, Bayburt, Türkiye.
BMC Pediatr. 2025 Mar 25;25(1):230. doi: 10.1186/s12887-025-05576-x.
Hormones are molecules that contribute significantly to mental and physical health due to their role in emotion regulation (ER) processes. However, the role and effect of hormones on the ER has not yet been fully elucidated. In this study, it was aimed to examine the salivary Brain-derived neurotrophic factor (BDNF) and cortisol hormone response to support ERS in primary school students depending on some parameters.
This cross-sectional and correlational study was conducted in the Eastern Black Sea Region of Türkiye between April 2023 and June 2023. In the sample selection, after the number of students was determined in proportional stratification, the sample selection method was made by simple random selection from each class list, first according to the school and then the grade level of each school. A total of 177 healthy students between the ages of 8 and 10 who attended these schools, were allowed to participate in the research by their families, and were volunteers, were included in the study. Data were collected using the Personal Information Form and the Emotion Regulation Scale for Children and saliva collection cups. Human-specific Brain-derived neurotrophic factor ELISA Kit (BT LAB, Cat.No E1302Hu, CHINA) for measuring BDNF levels in saliva; In measuring the level of cortisol hormone in saliva, Human Cortisol ELISA Kit (BT LAB, Cat.No E 1 003Hu, CHINA) was used in accordance with the procedure specified in the manufacturer's catalogue. Data were evaluated using the SPSS 26.0 for Windows (SPSS, Chicago, Il, USA) package program. Independent Samples Test and One-Way ANOVA test, correlation and Multiple Linear Regression analysis were used to evaluate the data. P <.01 and p <.05 significance levels were used as statistical significance values.
A statistically significant correlation was found between the mean total score of the Emotion Regulation Skills Scale for Children and the mean level of salivary BDNF, and a negative correlation between the mean level of salivary cortisol (p˂0.01).
Within the scope of the data obtained in our current study, BDNF levels were found to be high and cortisol hormone levels to be low in children with high ERS.
激素是一类分子，因其在情绪调节（ER）过程中的作用，对身心健康有重要影响。然而，激素对ER的作用和影响尚未完全阐明。本研究旨在根据一些参数，检测小学生唾液中脑源性神经营养因子（BDNF）和皮质醇激素反应，以支持情绪调节技能（ERS）。
本横断面相关性研究于2023年4月至2023年6月在土耳其黑海东部地区进行。在样本选择中，按比例分层确定学生人数后，采用简单随机抽样方法，先按学校，再按各学校的年级从每个班级名单中选取样本。共有177名年龄在8至10岁之间、就读于这些学校、经家长同意参与研究且为志愿者的健康学生纳入本研究。使用个人信息表、儿童情绪调节量表和唾液收集杯收集数据。采用人特异性脑源性神经营养因子ELISA试剂盒（BT LAB，产品编号E1302Hu，中国）检测唾液中BDNF水平；按照制造商目录中规定的程序，使用人皮质醇ELISA试剂盒（BT LAB，产品编号E1003Hu，中国）检测唾液中皮质醇激素水平。使用Windows版SPSS 26.0软件包程序（SPSS，美国伊利诺伊州芝加哥）对数据进行评估。采用独立样本检验、单因素方差分析、相关性分析和多元线性回归分析来评估数据。P <.01和P <.05显著性水平作为统计学显著性值。
儿童情绪调节技能量表的平均总分与唾液BDNF平均水平之间存在统计学显著相关性，与唾液皮质醇平均水平呈负相关（P˂0.01）。
在我们当前研究获得的数据范围内，发现ERS高的儿童BDNF水平高，皮质醇激素水平低。
