Razavi Fatemeh Sadat, Zokaee Hania, Sehat Mojtaba, Taghizadeh Mohsen, Motedayyen Hossein, Ghasemzadeh Hoseini Elaheh
School of Dentistry, Kashan University of Medical Sciences, Kashan, Iran.
Arthur Child Comprehensive Cancer Center, Cumming School of Medicine, University of Calgary, Calgary, Canada.
J Immunoassay Immunochem. 2025;46(3):303-315. doi: 10.1080/15321819.2025.2484645. Epub 2025 Mar 25.
Oral mucositis is considered as one of the most prevalent complications of chemotherapy or radiation therapy in cancerous tumors, which can interrupt the patient's treatment and nutrition. This study therefore aimed to evaluate the efficacy of ginger-honey mouthwash on the prevention of chemotherapy-induced oral mucositis in patients suffering from various cancers.
In this randomized clinical trial study, 70 patients receiving chemotherapy were divided into case and control groups. The former group ( = 34) received natural honey-ginger mouthwash and the latter ( = 36) used normal saline for 14 days. The presence and severity of oral mucositis, pain intensity, and other related characteristics were evaluated based on a two-part questionnaire (demographic and clinical information) and a checklist prepared from the protocols of the World Health Organization in each group.
During a 14-day intervention, patients received a 7-day intervention with ginger-honey mouthwash revealed a significant reduction in the mean severity of oral mucositis compared to the control group ( = 0.03). However, a 14-day intervention with ginger-honey mouthwash indicated no significant impact on the mean severity of oral mucositis ( = 0.6). In addition, no significant difference was observed in pain intensity between case and control groups during these 14 days.
This study suggests that a seven-day intervention with ginger-honey mouthwash has a beneficial effect on reducing the severity of mucositis in patients under chemotherapy, unlike a 14-day intervention. The honey-ginger mouthwash fails to have a significant effect on the pain intensity due to mucositis in patients undergoing chemotherapy.
口腔黏膜炎被认为是癌性肿瘤化疗或放疗最常见的并发症之一，它会中断患者的治疗和营养摄入。因此，本研究旨在评估姜蜜漱口水对预防各类癌症患者化疗引起的口腔黏膜炎的疗效。
在这项随机临床试验研究中，70名接受化疗的患者被分为病例组和对照组。前一组（n = 34）使用天然姜蜜漱口水，后一组（n = 36）使用生理盐水，为期14天。根据一份两部分问卷（人口统计学和临床信息）以及根据世界卫生组织方案编制的检查表，对每组口腔黏膜炎的存在和严重程度、疼痛强度及其他相关特征进行评估。
在为期14天的干预期间，与对照组相比，接受7天姜蜜漱口水干预的患者口腔黏膜炎平均严重程度显著降低（P = 0.03）。然而，14天的姜蜜漱口水干预对口腔黏膜炎平均严重程度无显著影响（P = 0.6）。此外，在这14天里，病例组和对照组之间的疼痛强度没有显著差异。
本研究表明，与14天的干预不同，7天的姜蜜漱口水干预对降低化疗患者黏膜炎的严重程度有有益效果。姜蜜漱口水对化疗患者因黏膜炎引起的疼痛强度没有显著影响。
