Nurhidayah Ikeu, Rustina Yeni, Hastono Sutanto Priyo, Mediani Henny Suzana
Department of Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Jalan Ir. Soekarno KM. 21, Jatinangor, Sumedang, West Java, 45363, Indonesia.
Department of Pediatric Nursing, Faculty of Nursing, Universitas Indonesia, Jalan Prof. Dr. Bahder Djohan, Depok, West Java, 16424, Indonesia.
BMC Complement Med Ther. 2024 Dec 18;24(1):415. doi: 10.1186/s12906-024-04710-z.
Mucositis is one of the common side effects of chemotherapy. This study aimed to identify the effects of honey on oral care interventions to reduce mucositis scores among children undergoing chemotherapy.
This pilot study was quasi-experimental with pre-post intervention with the control group. The study employed consecutive sampling, with 24 patients in the control and 24 in the intervention group. The intervention group received an oral care protocol using honey, whereas the control group received regular oral care. The data were collected using demographic information form and the Oral Assessment Guide (OAG) to assess mucositis. The intervention group received oral care intervention using honey (35 ml of honey applied topically in the oral cavity and 15 ml of honey used as a mouthwash and for lip care), which was given thrice daily for five days. The data were analyzed using percentage distributions, means, chi-square tests, dependent and independent t-tests, and multivariate analysis using analysis of covariance (ANCOVA).
The findings of this study showed that the intervention group experienced a significant reduction (-0.51 ± 0.66) in the average mucositis score after the intervention, whereas the control group experienced an increase in the mucositis score (3.84 ± 1.28) after controlling for confounding variables (p = 0.000).
This study revealed that oral care with honey effectively reduced chemotherapy-induced mucositis in children with cancer. These findings suggest that oral care with honey should be used as a nursing intervention for chemotherapy patients.
This clinical trial was retrospectively registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) with registration number ACTRN12624001313527 (29/10/2024).
黏膜炎是化疗常见的副作用之一。本研究旨在确定蜂蜜在口腔护理干预中对降低化疗儿童黏膜炎评分的作用。
本试点研究为准实验性研究，采用干预前后对照设计。研究采用连续抽样，对照组24例患者，干预组24例患者。干预组接受使用蜂蜜的口腔护理方案，而对照组接受常规口腔护理。使用人口统计学信息表和口腔评估指南（OAG）收集数据以评估黏膜炎。干预组接受使用蜂蜜的口腔护理干预（35毫升蜂蜜局部涂抹于口腔，15毫升蜂蜜用作漱口水和唇部护理），每天三次，持续五天。数据采用百分比分布、均值、卡方检验、相关和独立t检验以及使用协方差分析（ANCOVA）的多变量分析进行分析。
本研究结果表明，干预组在干预后平均黏膜炎评分显著降低（-0.51±0.66），而对照组在控制混杂变量后黏膜炎评分有所增加（3.84±1.28）（p = 0.000）。
本研究表明，蜂蜜口腔护理可有效降低癌症儿童化疗引起的黏膜炎。这些发现表明，蜂蜜口腔护理应作为化疗患者的护理干预措施。
本临床试验在澳大利亚新西兰临床试验注册中心（ANZCTR）进行回顾性注册，注册号为ACTRN12624001313527（2024年10月29日）。
