Bhartiya Manish, Kumar Jatinder, Arora Rahil, Dhiman Ankush
Department of Internal Medicine, Command Hospital, Pune, Maharashtra, India.
Department of Radiodiagnosis, Military Hospital Guwahati, Assam, India.
Ann Indian Acad Neurol. 2025 Mar 1;28(2):257-261. doi: 10.4103/aian.aian_921_24. Epub 2025 Mar 25.
High-altitude cerebral edema (HACE) is a severe form of altitude sickness characterized by headache, ataxia, and altered consciousness. This study aims to describe the clinical features, radiological findings, and outcomes of patients diagnosed with HACE. This study was conducted at a tertiary care hospital in northeastern India. Eleven consecutive patients diagnosed with HACE based on clinical criteria were included. Clinical data, demographics, radiological findings, and outcome were collected. All 11 patients were young males. Headache was the most common symptom, followed by ataxia. Uncommon findings included retinal hemorrhages in two patients. Cytotoxic lesions of the corpus callosum were present in two patients, while one had micro-hemorrhages in the splenium. All the patients had a good outcome. HACE is a rare but serious condition that requires early recognition and treatment. Diagnosis is primarily clinical, and radiological findings may be normal in some cases.
高原脑水肿（HACE）是高原病的一种严重形式，其特征为头痛、共济失调和意识改变。本研究旨在描述诊断为HACE的患者的临床特征、影像学表现及预后。本研究在印度东北部的一家三级护理医院进行。纳入了11例根据临床标准诊断为HACE的连续患者。收集了临床数据、人口统计学资料、影像学表现及预后情况。所有11例患者均为年轻男性。头痛是最常见的症状，其次是共济失调。不常见的表现包括2例患者出现视网膜出血。2例患者存在胼胝体的细胞毒性病变，1例患者在胼胝体压部有微出血。所有患者预后良好。HACE是一种罕见但严重的疾病，需要早期识别和治疗。诊断主要依靠临床，某些情况下影像学表现可能正常。
