痴呆治疗中的精神药理学展望。

Psychopharmacological prospectives in the treatment of dementia.

Antuono P, Amaducci L, Pazzagli A, Pepeu G

Department of Neurology, University of Florence, Italy.

Prog Neuropsychopharmacol. 1979;3(1-3):75-80. doi: 10.1016/0364-7722(79)90072-9.

Abstract

Dementias have a complex etiology and pathogenesis which should be carefully evaluated in order to attempt a medical treatment. 2. Drugs are among the most frequent causes of dementias, particularly drugs with anticholinergic properties. 3. A similarity between the mental symptoms of anticholinergic poisoning and senile dementia has been observed. 4. Recent investigations have also presented a decrease of cholinergic activity in postmortem material of subjects with Alzheimer's disease. Also a number of data suggest that recent memory would be related to changes in the metabolism of brain acetylcholine (Ach). 5. The possibility that drugs stimulating brain cholinergic mechanisms might be used in the treatment of dementias is envisaged.

摘要

痴呆症具有复杂的病因和发病机制，为尝试进行药物治疗，应仔细评估。2. 药物是导致痴呆症最常见的原因之一，尤其是具有抗胆碱能特性的药物。3. 已观察到抗胆碱能中毒的精神症状与老年痴呆症之间存在相似性。4. 最近的研究还表明，阿尔茨海默病患者死后脑组织中胆碱能活性降低。此外，大量数据表明近期记忆可能与脑乙酰胆碱（Ach）代谢变化有关。5. 设想了使用刺激脑胆碱能机制的药物治疗痴呆症的可能性。