Uhlmann A, Bräuninger W
Z Hautkr. 1985 May 15;60(10):774-6, 779-82.
As experimental findings indicated inhibitory action of aromatic retinoid on microtubule polymerisation and collagen metabolism of mesenchymal cells, we decided to treat 5 patients suffering from progressive systemic sclerosis as well as 3 patients with Sharp's syndrome with aromatic retinoid (Tigason). All 8 patients of this preliminary study responded positively to this therapy, but there were individual differences. The dosage corresponded to that applied in psoriasis. There were no severe side effects observed. In our opinion, these results justify the application of aromatic retinoid in patients suffering from progressive systemic sclerosis or Sharp's syndrome.
由于实验结果表明芳香维甲酸对间充质细胞的微管聚合和胶原代谢具有抑制作用，我们决定用芳香维甲酸（银屑灵）治疗5例进行性系统性硬化症患者以及3例夏普综合征患者。这项初步研究的所有8例患者对该疗法均有积极反应，但存在个体差异。剂量与治疗银屑病时所用剂量相当。未观察到严重的副作用。我们认为，这些结果证明芳香维甲酸可用于治疗进行性系统性硬化症或夏普综合征患者。
