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矢状窦血栓形成——幼儿肾病综合征的罕见并发症。

Sagittal sinus thrombosis - rare complication of nephrotic syndrome in a young child.

作者信息

Lupu Catalin Ionut, Vlad Raluca Maria

机构信息

Department of Pediatrics, "Grigore Alexandrescu" Emergency Children's Hospital, Bucharest, Romania.

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

Arch Clin Cases. 2025 Mar 25;12(1):54-58. doi: 10.22551/2025.46.1201.10313. eCollection 2025.

DOI:10.22551/2025.46.1201.10313
PMID:40135192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11934352/
Abstract

The nephrotic syndrome (NS) is caused by increased glomerular permeability. We report a case of NS in a 3-year-old girl, complicated with central nervous system venous thrombosis. Physical examination revealed anasarca (edema, pleurisy, and ascites), intensely foaming urine. The lab tests showed severe, non-selective proteinuria, marked hypoproteinemia, dyslipidemia; also associated with abnormal thyroid panel due to urinary binding protein loss. Once the diagnosis was established and pathogen-specific treatment was started, the clinical and paraclinical evolution were favorable. A prolonged right body seizure was the onset symptom of cerebral venous infarction due to sagittal sinus thrombosis. Short- and long-term outcomes of the thrombosis can be severe, so anticoagulant therapy was promptly initiated.

摘要

肾病综合征（NS）是由肾小球通透性增加引起的。我们报告一例3岁女孩患肾病综合征，并发中枢神经系统静脉血栓形成。体格检查发现全身水肿（水肿、胸膜炎和腹水），尿液泡沫严重。实验室检查显示严重的非选择性蛋白尿、明显的低蛋白血症、血脂异常；还因尿结合蛋白丢失导致甲状腺功能指标异常。一旦确诊并开始针对病原体的治疗，临床和辅助检查结果均良好。因矢状窦血栓形成导致的脑静脉梗死的首发症状是右侧身体长时间癫痫发作。血栓形成的短期和长期后果可能很严重，因此立即开始了抗凝治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/3e9043b9a57d/acc-12-01-10313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/8f7bb031e08f/acc-12-01-10313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/aca7baf3747e/acc-12-01-10313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/7a33887e171b/acc-12-01-10313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/3deceaf21958/acc-12-01-10313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/3e9043b9a57d/acc-12-01-10313-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/8f7bb031e08f/acc-12-01-10313-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/aca7baf3747e/acc-12-01-10313-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/7a33887e171b/acc-12-01-10313-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/3deceaf21958/acc-12-01-10313-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cec9/11934352/3e9043b9a57d/acc-12-01-10313-g005.jpg

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Thromboembolism in nephrotic syndrome: controversies and uncertainties.肾病综合征中的血栓栓塞：争议与不确定性。
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