Schumpelick V
Zentralbl Chir. 1985;110(5):257-70.
150 years after Beaumont duodenogastric reflux is still under discussion. The cytotoxic effect of bile acids and lysolecithin is proved experimentally, its clinical role, however is called in question. Whereas a pathogenetic role is demonstrated in stress ulcer formation, its role in chronic ulcer is still questionable. Whereas its role in secondary alkaline reflux oesophagitis can be shown clinically and experimentally, the function of duodenogastric reflux in primary reflux oesophagitis still remains to be elucidated. The question of duodenogastric reflux in the operated stomach is even more difficult. A deleterious effect is discussed by some authors however it is not proved clinically. There is no doubt about the effect of intestino-gastric reflux against stomal ulceration in gastro-jejunal reconstruction after gastrectomy.
在博蒙特(Beaumont)之后的150年里,十二指肠胃反流仍在讨论中。胆汁酸和溶血卵磷脂的细胞毒性作用已通过实验得到证实,但其临床作用仍受到质疑。虽然在应激性溃疡形成中已证明其致病作用,但其在慢性溃疡中的作用仍存在疑问。虽然其在继发性碱性反流性食管炎中的作用可通过临床和实验证明,但十二指肠胃反流在原发性反流性食管炎中的功能仍有待阐明。手术胃中的十二指肠胃反流问题更加棘手。一些作者讨论了其有害作用,但尚未得到临床证实。胃切除术后胃空肠重建中肠胃反流对吻合口溃疡的影响是毫无疑问的。