格拉斯哥预后评分在接受血液透析患者中的预后价值。

Prognostic value of Glasgow prognostic score in patients undergoing hemodialysis.

作者信息

Sakamoto Ryosuke, Torigoe Kenta, Abe Shinichi, Kitamura Mineaki, Funakoshi Satoshi, Takazono Takahiro, Sakamoto Noriho, Mukae Hiroshi, Nishino Tomoya

机构信息

Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan.

Nagasaki Renal Center, Nagasaki City, Nagasaki, Japan.

出版信息

Ther Apher Dial. 2025 Jun;29(3):357-364. doi: 10.1111/1744-9987.70014. Epub 2025 Mar 26.

DOI:10.1111/1744-9987.70014

PMID:40135657

Abstract

INTRODUCTION

Usefulness of the Glasgow prognostic score (GPS), modified GPS (mGPS), and high-sensitivity mGPS (HS-mGPS) in the prognosis of patients undergoing hemodialysis remains unclear. This study aimed to investigate this.

METHODS

The GPS, mGPS, and HS-mGPS were calculated retrospectively in 339 patients undergoing hemodialysis; their association with all-cause mortality was analyzed using the Kaplan-Meier method and Cox proportional hazards models.

RESULTS

Survival rates decreased according to the GPS (0, 1, and 2), but were similar between the mGPS and HS-mGPS. In the multivariate Cox proportional hazards model, the GPS, not the mGPS or HS-mGPS, was associated with a higher risk of all-cause mortality in patients with scores 1 (hazard ratio [HR]: 1.76, 95% confidence interval [CI]: 1.29-2.42, p = 0.0004) and 2 (HR: 2.87, 95% CI: 1.91-4.32, p < 0.0001) compared with score 0.

CONCLUSIONS

The GPS classified patients into poor prognostic risk groups more clearly than other scores.

摘要

引言

格拉斯哥预后评分（GPS）、改良GPS（mGPS）和高敏mGPS（HS-mGPS）在接受血液透析患者预后评估中的作用仍不明确。本研究旨在对此进行调查。

方法

回顾性计算339例接受血液透析患者的GPS、mGPS和HS-mGPS；采用Kaplan-Meier法和Cox比例风险模型分析它们与全因死亡率的关联。

结果

生存率根据GPS（0、1和2）降低，但mGPS和HS-mGPS之间相似。在多变量Cox比例风险模型中，与评分为0的患者相比，GPS而非mGPS或HS-mGPS与评分为1（风险比[HR]：1.76，95%置信区间[CI]：1.29 - 2.42，p = 0.0004）和2（HR：2.87，95% CI：1.91 - 4.32，p < 0.0001）的患者全因死亡风险更高相关。