人乳头瘤病毒38 E6/E7转化角质形成细胞中致癌性ΔNp73α亚型的相互作用组
Interactome of the oncogenic ΔNp73α isoform in human papillomavirus 38 E6/E7-transformed keratinocytes.
作者信息
Negroni Luc, Taverniti Valerio, Tommasino Massimo, Zanier Katia
机构信息
Proteomics Platform, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.
International Agency for Research on Cancer (IARC), World Health Organization, Lyon, Auvergne-Rhône-Alpes, France.
出版信息
Microbiol Resour Announc. 2025 Apr 10;14(4):e0107124. doi: 10.1128/mra.01071-24. Epub 2025 Mar 26.
ΔNp73α is a major oncogenic isoform of tumor suppressor p73. Here, we report ΔNp73α protein-binding partners in the organelle and cytoplasmic compartments of a cellular model consisting of human keratinocytes transformed by the E6 and E7 oncoproteins of the β-HPV38 virus associated with non-melanoma skin cancer.
ΔNp73α是肿瘤抑制因子p73的一种主要致癌异构体。在此，我们报告了在由与非黑色素瘤皮肤癌相关的β - HPV38病毒的E6和E7癌蛋白转化的人角质形成细胞组成的细胞模型的细胞器和细胞质区室中的ΔNp73α蛋白结合伙伴。
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