乳腺癌与肿瘤微环境：免疫细胞的关键作用

Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune Cells.

作者信息

Moura Tânia, Laranjeira Paula, Caramelo Olga, Gil Ana M, Paiva Artur

机构信息

Flow Cytometry Unit, Department of Clinical Pathology, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, 3000-076 Coimbra, Portugal.

Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

出版信息

Curr Oncol. 2025 Feb 28;32(3):143. doi: 10.3390/curroncol32030143.

DOI:10.3390/curroncol32030143

PMID:40136347

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11941043/

Abstract

Breast cancer is the most common type of cancer in women and the second leading cause of death by cancer. Despite recent advances, the mortality rate remains high, underlining the need to develop new therapeutic approaches. The complex interaction between cancer cells and the tumor microenvironment (TME) is crucial in determining tumor progression, therapy response, and patient prognosis. Understanding the role of immune cells in carcinogenesis and tumor progression can help improve targeted therapeutic options, increasing the likelihood of a favorable prognosis. Therefore, this review aims to critically analyze the complex interaction between tumor cells and immune cells, emphasizing the clinical and therapeutic implications. Additionally, we explore advances in immunotherapies, with a focus on immune checkpoint inhibitors.

摘要

乳腺癌是女性中最常见的癌症类型，也是癌症死亡的第二大主要原因。尽管最近取得了进展，但死亡率仍然很高，这凸显了开发新治疗方法的必要性。癌细胞与肿瘤微环境（TME）之间的复杂相互作用在决定肿瘤进展、治疗反应和患者预后方面至关重要。了解免疫细胞在致癌作用和肿瘤进展中的作用有助于改善靶向治疗选择，增加预后良好的可能性。因此，本综述旨在批判性地分析肿瘤细胞与免疫细胞之间的复杂相互作用，强调其临床和治疗意义。此外，我们还探讨了免疫疗法的进展，重点是免疫检查点抑制剂。