Vanderheyden J E, Dumont J P, Dekoninck W J, Mendlewicz J
Acta Neurol Belg. 1985 May-Jul;85(3):171-81.
Two patients with movement disorders are described and neurochemically studied. The first subject concerns a central anticholinergic syndrome in a 83 years old man treated with l-dopa and amantadine for red nucleus tremor. The second one is an association of parkinsonism and chorea in a 76 years old woman presenting with FAHR's syndrome. In both cases, CSF HVA levels were measured before and after oral probenecid load. The observations confirm the usefulness of this neurochemical strategy in order to classify aging patients with parkinsonism into dopasensitive and doparesistant groups.
描述了两名患有运动障碍的患者并对其进行了神经化学研究。第一个病例是一名83岁男性，因红核震颤接受左旋多巴和金刚烷胺治疗，出现了中枢抗胆碱能综合征。第二个病例是一名76岁女性，患有帕金森病和舞蹈症，并伴有 Fahr 综合征。在这两个病例中，均在口服丙磺舒负荷前后测量了脑脊液中高香草酸（HVA）水平。这些观察结果证实了这种神经化学策略在将老年帕金森病患者分为对多巴胺敏感和不敏感组方面的有用性。
