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带状疱疹:发生、并发症及复发的危险因素,重点关注免疫功能低下患者

Herpes Zoster: Risk Factors for Occurrence, Complications, and Recurrence with a Focus on Immunocompromised Patients.

作者信息

Oleszko Michał, Zapolnik Paweł, Kmiecik Wojciech, Czajka Hanna

机构信息

College of Medical Sciences, University of Rzeszów, 35-315 Rzeszów, Poland.

St. Louis Provincial Specialist Children's Hospital, 31-503 Kraków, Poland.

出版信息

Diseases. 2025 Feb 26;13(3):71. doi: 10.3390/diseases13030071.

DOI:10.3390/diseases13030071
PMID:40136611
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11940898/
Abstract

BACKGROUND

The varicella-zoster virus is a highly contagious human herpesvirus that primarily causes varicella (chickenpox) as an initial infection, targeting T cells, neurons, as well as skin cells, and can later reactivate to cause herpes zoster (shingles). Following reactivation, the varicella-zoster virus infection can lead to severe complications, the most common of which is postherpetic neuralgia. Risk factors include aging, immunosuppression, chronic diseases such as diabetes, cardiovascular disorders, respiratory conditions, and others.

OBJECTIVE

In this article, we present an analysis of factors increasing the risk of herpes zoster occurrence, complications, and recurrences (in particular in immunocompromised patients).

摘要

背景

水痘带状疱疹病毒是一种高度传染性的人类疱疹病毒,初次感染主要引起水痘,靶向T细胞、神经元以及皮肤细胞,随后可重新激活引发带状疱疹。重新激活后,水痘带状疱疹病毒感染可导致严重并发症,其中最常见的是带状疱疹后神经痛。危险因素包括年龄增长、免疫抑制、糖尿病等慢性疾病、心血管疾病、呼吸系统疾病等。

目的

在本文中,我们对增加带状疱疹发生、并发症及复发风险的因素(尤其是免疫功能低下患者)进行分析。

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1
Herpes Zoster: Risk Factors for Occurrence, Complications, and Recurrence with a Focus on Immunocompromised Patients.带状疱疹:发生、并发症及复发的危险因素,重点关注免疫功能低下患者
Diseases. 2025 Feb 26;13(3):71. doi: 10.3390/diseases13030071.
2
[Reactivation of herpes zoster infection by varicella-zoster virus].[水痘-带状疱疹病毒引起的带状疱疹感染再激活]
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[Varicella-pox virus infection: features of the course, clinical manifestations, complications, and possibilities for prevention].[水痘-痘病毒感染:病程特点、临床表现、并发症及预防措施]
Ter Arkh. 2021 Nov 15;93(11):1401-1406. doi: 10.26442/00403660.2021.11.201192.
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Clinical Features of Varicella-Zoster Virus Infection.水痘-带状疱疹病毒感染的临床特征。
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Varicella-zoster virus: overview and clinical manifestations.水痘-带状疱疹病毒:概述及临床表现
Semin Dermatol. 1996 Jun;15(2 Suppl 1):4-7.
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Nat Rev Dis Primers. 2015 Jul 2;1:15016. doi: 10.1038/nrdp.2015.16.
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Management of herpes zoster (shingles) and postherpetic neuralgia.带状疱疹(缠腰龙)及带状疱疹后神经痛的管理
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Varicella-zoster virus: a re-emerging infection.水痘带状疱疹病毒:一种再度流行的感染性疾病。
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引用本文的文献

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Understanding Attitudes Toward Zoster Vaccination in the Hospital Setting: A Multidisciplinary Model to Contrast Vaccine Hesitancy in Fragile Patients-A Prospective Longitudinal Observational Study.了解医院环境中对带状疱疹疫苗接种的态度:一种对比脆弱患者疫苗犹豫情况的多学科模型——一项前瞻性纵向观察研究。
Vaccines (Basel). 2025 Aug 8;13(8):843. doi: 10.3390/vaccines13080843.

本文引用的文献

1
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids.水痘带状疱疹病毒在成熟的 hiPSC 衍生神经球中再现其免疫逃避行为。
Front Immunol. 2024 Sep 16;15:1458967. doi: 10.3389/fimmu.2024.1458967. eCollection 2024.
2
Exploring the Link between Varicella-Zoster Virus, Autoimmune Diseases, and the Role of Recombinant Zoster Vaccine.探讨水痘-带状疱疹病毒、自身免疫性疾病与重组带状疱疹疫苗作用之间的关联。
Biomolecules. 2024 Jun 22;14(7):739. doi: 10.3390/biom14070739.
3
The Incidence of Herpes Zoster Complications: A Systematic Literature Review.带状疱疹并发症的发病率:一项系统文献综述。
Infect Dis Ther. 2024 Jul;13(7):1461-1486. doi: 10.1007/s40121-024-01002-4. Epub 2024 Jun 19.
4
Herpes Zoster Recurrence: A Narrative Review of the Literature.带状疱疹复发:文献综述
Dermatol Ther (Heidelb). 2024 Mar;14(3):569-592. doi: 10.1007/s13555-024-01101-7. Epub 2024 Feb 28.
5
Time to talk to adults with rheumatic diseases about herpes zoster vaccination.是时候与风湿性疾病患者谈论带状疱疹疫苗接种了。
Lancet Rheumatol. 2024 Apr;6(4):e247-e251. doi: 10.1016/S2665-9913(24)00019-5. Epub 2024 Feb 16.
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Hospitalizations of patients with herpes zoster in Poland during 2012-2021: A population-based study.2012-2021 年波兰住院带状疱疹患者情况:一项基于人群的研究。
Vaccine. 2024 Mar 19;42(8):1928-1933. doi: 10.1016/j.vaccine.2024.02.022. Epub 2024 Feb 17.
7
Risk factors for herpes zoster infections: a systematic review and meta-analysis unveiling common trends and heterogeneity patterns.疱疹性感染的风险因素:系统综述和荟萃分析揭示了常见趋势和异质性模式。
Infection. 2024 Jun;52(3):1009-1026. doi: 10.1007/s15010-023-02156-y. Epub 2024 Jan 18.
8
Designing a polyvalent vaccine targeting multiple strains of varicella zoster virus using integrated bioinformatics approaches.使用综合生物信息学方法设计一种针对多种水痘带状疱疹病毒株的多价疫苗。
Front Microbiol. 2023 Nov 17;14:1291868. doi: 10.3389/fmicb.2023.1291868. eCollection 2023.
9
Long term effectiveness of live herpes zoster vaccine.带状疱疹活疫苗的长期有效性。
BMJ. 2023 Nov 8;383:2497. doi: 10.1136/bmj.p2497.
10
Hospitalization burden related to herpes zoster infection during the COVID-19 pandemic in Spain (2020-2021).西班牙 COVID-19 大流行期间(2020-2021 年)与带状疱疹感染相关的住院负担。
Hum Vaccin Immunother. 2023 Aug;19(2):2256047. doi: 10.1080/21645515.2023.2256047. Epub 2023 Oct 6.