为支链氨基酸用于神经病理学奠定基础：单次口服剂量能否使全身水平升高数小时？
Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels?
作者信息
Mathew Ezek, Jones Nathan, Dews McKinley, Neal Dominique, Cohen Anders
机构信息
Department of Microbiology and Immunology, The University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA.
Department of Neurological Surgery, The Brooklyn Hospital Center, 121 DeKalb Avenue, Brooklyn, NY 11201, USA.
出版信息
Diseases. 2025 Mar 6;13(3):76. doi: 10.3390/diseases13030076.
BACKGROUND
Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have previously been reported in hospital settings, the metabolism of a single recommended dose of over-the-counter branched-chain amino acids has yet to be elucidated.
METHODS
We analyzed a patented branched-chain amino acid product to assess its metabolism in 10 healthy adults.
RESULTS
Over the defined time points, measured levels of branched-chain amino acids remained significantly elevated when compared to the physiological baseline. The elevations in measured plasma levels indicate that a single oral dose is a viable intake option for increasing levels of branched-chain amino acids.
CONCLUSIONS
This information can be leveraged to better plan branched-chain amino acid-based treatment doses in order to treat pathologies such as brain injury.
背景
最近的研究表明，支链氨基酸具有神经保护和神经修复作用。现在建议在进行接触性运动前服用支链氨基酸补充剂以减少脑震荡。虽然此前在医院环境中已报道过支链氨基酸的峰值和谷值，但非处方支链氨基酸单次推荐剂量的代谢情况尚未阐明。
方法
我们分析了一种获得专利的支链氨基酸产品，以评估其在10名健康成年人中的代谢情况。
结果
在规定的时间点内，与生理基线相比，测得的支链氨基酸水平仍显著升高。血浆水平的升高表明，单次口服剂量是增加支链氨基酸水平的可行摄入方式。
结论
这些信息可用于更好地规划基于支链氨基酸的治疗剂量，以治疗诸如脑损伤等病症。
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