Menon Lakshmi Krishna, Wisniak Ania, Regard Simon, Stringhini Silvia, Guessous Idris, Balavoine Jean-François, Kherad Omar
Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Institute of Global Health, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.
Epidemiologia (Basel). 2025 Mar 11;6(1):14. doi: 10.3390/epidemiologia6010014.
The objective of this study was to examine the impact of varying levels of non-pharmaceutical interventions (NPIs) on COVID-19 transmission in nursing homes during the first wave of the pandemic.
BACKGROUND/OBJECTIVES: The primary aim involved exploring qualitative insights from staff and management regarding the implementation of NPIs. The secondary aim was to determine the cumulative incidence of PCR-confirmed COVID-19 cases among residents. Incident rate ratios (IRRs) were the calculated levels of NPI restrictiveness.
We used a mixed methodology to identify factors that might have affected COVID-19 expansion in nursing homes in the canton of Geneva, Switzerland. For the qualitative component, we interviewed the Attending Physicians and/or Director of each nursing home. In the quantitative component, we calculated incident rate ratios (IRRs) for infection between the three levels of COVID-19-related measures taken in these nursing homes, and the cumulative incidence of PCR-confirmed COVID-19 cases in their resident population. This study was conducted in 12 nursing homes located in the canton of Geneva, Switzerland, between 1 March 2020, and 1 June 2020.
Most nursing homes mandated NPIs for their staff and residents during the first wave of COVID-19. We found an equal distribution of maximally ( = 4), moderately ( = 4), and minimally ( = 4) restrictive NPIs for nursing home workers and residents. The extent of NPIs implemented was not shown to be significantly associated with the cumulative incidence of COVID-19 cases among residents (maximally restrictive IRR = 3.90, 95%CI 0.82-45.54, = 0.184; moderately restrictive IRR = 3.55, 95%CI 0.75-41.42, = 0.212; minimally restrictive IRR = reference).
Nursing homes in our study showed high variability in which NPIs, and to what extent, they implemented, with no significant relationship between the restrictiveness of NPIs and COVID-19 incidence among nursing home residents. This suggests that other factors influence the transmission of COVID-19 in these settings. Future research should explore additional determinants and the balance between strict NPIs and the overall well-being of residents.
本研究的目的是考察在疫情第一波期间,不同水平的非药物干预措施(NPIs)对养老院中新冠病毒传播的影响。
背景/目标:主要目的是探索工作人员和管理层对实施非药物干预措施的定性见解。次要目的是确定居民中经聚合酶链反应(PCR)确诊的新冠病例的累积发病率。发病率比(IRRs)是计算得出的非药物干预措施的限制程度水平。
我们采用混合方法来确定可能影响瑞士日内瓦州养老院中新冠病毒传播的因素。对于定性部分,我们采访了每家养老院的主治医生和/或院长。在定量部分,我们计算了这些养老院采取的与新冠病毒相关的三个措施水平之间的感染发病率比(IRRs),以及其居民中经PCR确诊的新冠病例的累积发病率。本研究于2020年3月1日至2020年6月1日在瑞士日内瓦州的12家养老院进行。
在新冠疫情第一波期间,大多数养老院对其工作人员和居民强制实施非药物干预措施。我们发现,针对养老院工作人员和居民,最大限度(=4)、适度(=4)和最小限度(=4)限制的非药物干预措施分布均等。实施的非药物干预措施的程度与居民中新冠病例的累积发病率未显示出显著关联(最大限度限制的发病率比=3.90,95%置信区间0.82 - 45.54,P = 0.184;适度限制的发病率比=3.55,95%置信区间0.75 - 41.42,P = 0.212;最小限度限制的发病率比=参考值)。
我们研究中的养老院在实施哪些非药物干预措施以及实施程度方面表现出高度差异,非药物干预措施的限制程度与养老院居民中的新冠发病率之间没有显著关系。这表明其他因素影响了这些环境中新冠病毒的传播。未来的研究应探索其他决定因素以及严格的非药物干预措施与居民整体福祉之间的平衡。